3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid

Base Information

Chemical Name:3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid
CAS No.:932367-36-7
Molecular Formula:C₂₄H₂₄F₃NO₄
Molecular Weight:447.454
Hs Code.:

Synonyms:3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid

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Chemical Property of 3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid

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Technology Process of 3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid

There total 5 articles about 3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932367-99-2
C₂₈H₃₂F₃NO₄

: 932367-36-7
3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1016/j.bmcl.2007.01.047

Reference yield:

: 459811-03-1
7-bromo-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinoline-2-one

: 932367-36-7
3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: aq. K₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / Heating

2: DMPU; n-BuLi / tetrahydrofuran / -78 - 0 °C

3: TFA / CH₂Cl₂ / 8 h / 20 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; potassium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene; 1: Suzuki coupling / 2: Horner-Emmons reaction;
DOI:10.1016/j.bmcl.2007.01.047

Reference yield:

: 459811-02-0
7-bromo-4,4,6-trimethyl-3,4-dihydro-1H-quinoline-2-one

: 932367-36-7
3-[3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-qiuinolin-7-yl)-4-trifluoromethoxy-phenyl]-acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: KOH / dimethylsulfoxide / 12 h / 20 °C

2: aq. K₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / Heating

3: DMPU; n-BuLi / tetrahydrofuran / -78 - 0 °C

4: TFA / CH₂Cl₂ / 8 h / 20 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium hydroxide; n-butyllithium; potassium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; toluene; 2: Suzuki coupling / 3: Horner-Emmons reaction;
DOI:10.1016/j.bmcl.2007.01.047