2-(4-methoxyphenyl)-7,14-dioxa-1-azadispiro[4.2.5.2]pentadec-1-ene 1-oxide

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Chemical Name:2-(4-methoxyphenyl)-7,14-dioxa-1-azadispiro[4.2.5.2]pentadec-1-ene 1-oxide
CAS No.:1294479-79-0
Molecular Formula:C₁₉H₂₅NO₄
Molecular Weight:331.412
Hs Code.:

Synonyms:2-(4-methoxyphenyl)-7,14-dioxa-1-azadispiro[4.2.5.2]pentadec-1-ene 1-oxide

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Chemical Property of 2-(4-methoxyphenyl)-7,14-dioxa-1-azadispiro[4.2.5.2]pentadec-1-ene 1-oxide

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Technology Process of 2-(4-methoxyphenyl)-7,14-dioxa-1-azadispiro[4.2.5.2]pentadec-1-ene 1-oxide

There total 3 articles about 2-(4-methoxyphenyl)-7,14-dioxa-1-azadispiro[4.2.5.2]pentadec-1-ene 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 176643-32-6
7,14-dioxa-1-azaspiro<4.2.5.2>pentadec-1-ene 1-oxide

: 1294479-79-0
2-(4-methoxyphenyl)-7,14-dioxa-1-azadispiro[4.2.5.2]pentadec-1-ene 1-oxide

Guidance literature:: 1-bromo-4-methoxy-benzene; With magnesium; ethylene dibromide; In tetrahydrofuran; for 3h; Reflux; Inert atmosphere;

7,14-dioxa-1-azaspiro<4.2.5.2>pentadec-1-ene 1-oxide; In tetrahydrofuran; at -10 - 20 ℃; Inert atmosphere;

With ammonia; copper diacetate; In 1,4-dioxane; dichloromethane; water; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2011.02.018

Reference yield:

: 1294479-77-8
3-[2-(1,3-dithian-2-yl)ethyl]-3-nitro-1,5-dioxaspiro[5.5]undecane

: 1294479-79-0
2-(4-methoxyphenyl)-7,14-dioxa-1-azadispiro[4.2.5.2]pentadec-1-ene 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminium; mercury dichloride / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

1.2: 2 h / 45 °C

2.1: magnesium; ethylene dibromide / tetrahydrofuran / 3 h / Reflux; Inert atmosphere

2.2: -10 - 20 °C / Inert atmosphere

2.3: 24 h / 20 °C

With magnesium; ethylene dibromide; aluminium; mercury dichloride; In tetrahydrofuran; water;
DOI:10.1016/j.tetlet.2011.02.018

Reference yield:

: 176643-31-5
3-(2-formylethyl)-3-nitro-1,5-dioxaspiro[5.5]undecane

: 1294479-79-0
2-(4-methoxyphenyl)-7,14-dioxa-1-azadispiro[4.2.5.2]pentadec-1-ene 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 2 h / 20 °C

2.1: aluminium; mercury dichloride / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

2.2: 2 h / 45 °C

3.1: magnesium; ethylene dibromide / tetrahydrofuran / 3 h / Reflux; Inert atmosphere

3.2: -10 - 20 °C / Inert atmosphere

3.3: 24 h / 20 °C

With boron trifluoride diethyl etherate; magnesium; ethylene dibromide; aluminium; mercury dichloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetlet.2011.02.018