dimethyl 2',4'a-dimethyl-2-[[4-[3,5,7-tris[4-(ethoxycarbonyl)phenyl]-1-adamantyl]phenyl]ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

Base Information

• Chemical Name: dimethyl 2',4'a-dimethyl-2-[[4-[3,5,7-tris[4-(ethoxycarbonyl)phenyl]-1-adamantyl]phenyl]ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate
• CAS No.: 1239233-76-1
• Molecular Formula: C₇₀H₆₄N₂O₁₀
• Molecular Weight: 1093.29

Synonyms:dimethyl 2',4'a-dimethyl-2-[[4-[3,5,7-tris[4-(ethoxycarbonyl)phenyl]-1-adamantyl]phenyl]ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

Chemical Property of dimethyl 2',4'a-dimethyl-2-[[4-[3,5,7-tris[4-(ethoxycarbonyl)phenyl]-1-adamantyl]phenyl]ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

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Technology Process of dimethyl 2',4'a-dimethyl-2-[[4-[3,5,7-tris[4-(ethoxycarbonyl)phenyl]-1-adamantyl]phenyl]ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

There total 4 articles about dimethyl 2',4'a-dimethyl-2-[[4-[3,5,7-tris[4-(ethoxycarbonyl)phenyl]-1-adamantyl]phenyl]ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

dimethyl 2-ethynyl-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate (1239233-47-6) + 1-(4-iodophenyl)-3,5,7-tris[4-(ethoxycarbonyl)phenyl]adamantane (1239233-71-6) → dimethyl 2',4'a-dimethyl-2-[[4-[3,5,7-tris[4-(ethoxycarbonyl)phenyl]-1-adamantyl]phenyl]ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate (1239233-76-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; diethylamine; triphenylphosphine; In tetrahydrofuran; at 45 ℃; for 15h; Sealed vessel; Inert atmosphere;

DOI:10.1007/s00706-010-0267-7

Reference yield: 52.0%

dimethyl 2-iodo-2'-4a'-dimethyl-4a'H-spiro[fluorene-9,5'-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate (1210519-12-2) + 1-(4-ethynylphenyl)-3,5,7-tris-(4-carboethoxyphenyl)adamantane → dimethyl 2',4'a-dimethyl-2-[[4-[3,5,7-tris[4-(ethoxycarbonyl)phenyl]-1-adamantyl]phenyl]ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate (1239233-76-1)

Guidance literature:

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 40 ℃; for 6h; Inert atmosphere;

DOI:10.1002/poc.1669

Reference yield: 18.0%

C25H21BrN2O4 (1269613-02-6) + 1-(4-ethynylphenyl)-3,5,7-tris-(4-carboethoxyphenyl)adamantane → dimethyl 2',4'a-dimethyl-2-[[4-[3,5,7-tris[4-(ethoxycarbonyl)phenyl]-1-adamantyl]phenyl]ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate (1239233-76-1)

Guidance literature:

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 40 ℃; for 6h; Inert atmosphere;

DOI:10.1002/poc.1669

upstream raw materials:

dimethyl 2-ethynyl-2',4'a-dimethylspiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

1-(4-iodophenyl)-3,5,7-tris[4-(ethoxycarbonyl)phenyl]adamantane

dimethyl 2-iodo-2'-4a'-dimethyl-4a'H-spiro[fluorene-9,5'-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

C₇₀H₆₄N₂O₁₀

Downstream raw materials:

C₇₀H₆₄N₂O₁₀

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