{3-[(2-Azido-ethyl)-benzyloxycarbonyl-amino]-propyl}-carbamic acid benzyl ester

Base Information

Chemical Name:{3-[(2-Azido-ethyl)-benzyloxycarbonyl-amino]-propyl}-carbamic acid benzyl ester
CAS No.:204061-19-8
Molecular Formula:C₂₁H₂₅N₅O₄
Molecular Weight:411.461
Hs Code.:

Synonyms:{3-[(2-Azido-ethyl)-benzyloxycarbonyl-amino]-propyl}-carbamic acid benzyl ester

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Chemical Property of {3-[(2-Azido-ethyl)-benzyloxycarbonyl-amino]-propyl}-carbamic acid benzyl ester

Chemical Property:

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Technology Process of {3-[(2-Azido-ethyl)-benzyloxycarbonyl-amino]-propyl}-carbamic acid benzyl ester

There total 6 articles about {3-[(2-Azido-ethyl)-benzyloxycarbonyl-amino]-propyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methanesulfonic acid 2-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-ethyl ester

: 204061-19-8
{3-[(2-Azido-ethyl)-benzyloxycarbonyl-amino]-propyl}-carbamic acid benzyl ester

Guidance literature:: With sodium azide; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Yield given;
DOI:10.1002/(SICI)1521-3765(199801)4:1<137::AID-CHEM137>3.0.CO;2-2

Reference yield:

: 174626-34-7
N-(benzyloxycarbonyl)-3-amino-1-propyl methanesulfonate

: 204061-19-8
{3-[(2-Azido-ethyl)-benzyloxycarbonyl-amino]-propyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / CHCl₃ / 0.5 h

2: Et₃N, DMAP / CH₂Cl₂ / 5 h

3: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

4: 92 percent / TBAF / tetrahydrofuran / 2 h

5: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

6: NaN₃, NaI / dimethylformamide / 2 h / 80 °C

With dmap; sodium azide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1521-3765(199801)4:1<137::AID-CHEM137>3.0.CO;2-2

Reference yield:

: 142253-82-5
{3-[Benzyloxycarbonyl-(2-hydroxy-ethyl)-amino]-propyl}-carbamic acid benzyl ester

: 204061-19-8
{3-[(2-Azido-ethyl)-benzyloxycarbonyl-amino]-propyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

2: NaN₃, NaI / dimethylformamide / 2 h / 80 °C

With sodium azide; triethylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1521-3765(199801)4:1<137::AID-CHEM137>3.0.CO;2-2