N-[5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide

Base Information

• Chemical Name: N-[5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide
• CAS No.: 1443542-59-3
• Molecular Formula: C₁₇H₁₅N₃S
• Molecular Weight: 293.392
• Mol file: 1443542-59-3.mol

Synonyms:N-[5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide

Chemical Property of N-[5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide

There total 1 articles about N-[5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4-thiomethoxyphenyl)boronic acid (98546-51-1) + pyridinium N-<2'-(5'-bromopyridyl)>aminide (157020-26-3) → N-[5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide (1443542-59-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; for 12h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2013.05.065

Reference yield: 91.0%

N-[5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide (1443542-59-3) → N-[3-bromo-5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide (1443542-69-5)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 3h; chemoselective reaction;

DOI:10.1016/j.tet.2013.05.065

Reference yield:

N-[5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide (1443542-59-3) → 3-bromo-5-(4-methylthiophenyl)-2-pyridinamine (1443542-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / dichloromethane / 3 h / 20 °C

2: formic acid; triethylamine; platinum on carbon / acetonitrile / Cooling with ice; Reflux

With N-Bromosuccinimide; formic acid; platinum on carbon; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2013.05.065

upstream raw materials:

(4-thiomethoxyphenyl)boronic acid

pyridinium N-<2'-(5'-bromopyridyl)>aminide

Downstream raw materials:

N-[3-bromo-5-(4-methylthiophenyl)pyridin-2-yl]pyridin-1-ium-1-aminide

3-bromo-5-(4-methylthiophenyl)-2-pyridinamine

3-bromo-5-(4-methylthiophenyl)-2(1H)-pyridinone