Technology Process of 2-[(1-methylethyl)amino]-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile
There total 7 articles about 2-[(1-methylethyl)amino]-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1.25 h / 100 °C / Inert atmosphere
2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 60 °C / Reflux
3: pyridine / toluene / 2 h / Reflux
4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C
5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
pyridine; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / 0.25 h
2: pyridine / toluene / 2 h / Reflux
3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C
4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
pyridine; oxalyl dichloride; sodium hydride; trifluoroacetic acid;
N,N-dimethyl-formamide;
In
dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;