3-((1S,2R)-1,2-Dimethyl-6-oxo-cyclohexyl)-propionic acid methyl ester

Base Information

• Chemical Name: 3-((1S,2R)-1,2-Dimethyl-6-oxo-cyclohexyl)-propionic acid methyl ester
• CAS No.: 234077-99-7
• Molecular Formula: C₁₂H₂₀O₃
• Molecular Weight: 212.289
• Mol file: 234077-99-7.mol

Synonyms:3-((1S,2R)-1,2-Dimethyl-6-oxo-cyclohexyl)-propionic acid methyl ester

Chemical Property of 3-((1S,2R)-1,2-Dimethyl-6-oxo-cyclohexyl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((1S,2R)-1,2-Dimethyl-6-oxo-cyclohexyl)-propionic acid methyl ester

There total 6 articles about 3-((1S,2R)-1,2-Dimethyl-6-oxo-cyclohexyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H23N + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 3-((1S,2R)-1,2-Dimethyl-6-oxo-cyclohexyl)-propionic acid methyl ester (234077-99-7)

Guidance literature:

C₁₆H₂₃N; acrylic acid methyl ester; With hydroquinone; at 0 - 55 ℃; for 85h; Inert atmosphere; Sealed tube;

With acetic acid; In water; at 60 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.202004847

Reference yield:

(2RS,3R)-2,3-dimethylcyclohexanone (234078-11-6) → 3-((1S,2R)-1,2-Dimethyl-6-oxo-cyclohexyl)-propionic acid methyl ester (234077-99-7)

Guidance literature:

Multi-step reaction with 3 steps

1: TsOH / benzene / 24 h / Heating

2: 168 h / Ambient temperature

3: aq. AcOH / 1 h / 60 °C

With toluene-4-sulfonic acid; acetic acid; In benzene;

DOI:10.1016/S0957-4166(99)00067-1

Reference yield:

3-{(1S,2R)-1,2-Dimethyl-6-[(E)-(S)-1-phenyl-ethylimino]-cyclohexyl}-propionic acid methyl ester → 3-((1S,2R)-1,2-Dimethyl-6-oxo-cyclohexyl)-propionic acid methyl ester (234077-99-7)

Guidance literature:

With acetic acid; at 60 ℃; for 1h; Yield given;

DOI:10.1016/S0957-4166(99)00067-1

upstream raw materials:

acrylic acid methyl ester

(2RS,3R)-2,3-dimethylcyclohexanone

Downstream raw materials:

<1'S,6'R>-3-(1',6'-dimethyl-2'-oxocyclohexyl)propanal

(2S,3R)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-2,3-dimethyl-cyclohexanol

tert-Butyl-diphenyl-[3-((1S,6R)-1,2,6-trimethyl-cyclohex-2-enyl)-propoxy]-silane

3-((1S,6R)-1,2,6-Trimethyl-cyclohex-2-enyl)-propan-1-ol