1-(3-cyanophenyl)-5-[(4'-(N-imidazolyl)phenyl)aminocarbonyl]-3-trifluoromethyl-pyrazole

Base Information

• Chemical Name: 1-(3-cyanophenyl)-5-[(4'-(N-imidazolyl)phenyl)aminocarbonyl]-3-trifluoromethyl-pyrazole
• CAS No.: 209955-42-0
• Molecular Formula: C₂₁H₁₃F₃N₆O
• Molecular Weight: 422.369
• Mol file: 209955-42-0.mol

Synonyms:1-(3-cyanophenyl)-5-[(4'-(N-imidazolyl)phenyl)aminocarbonyl]-3-trifluoromethyl-pyrazole

Chemical Property of 1-(3-cyanophenyl)-5-[(4'-(N-imidazolyl)phenyl)aminocarbonyl]-3-trifluoromethyl-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-cyanophenyl)-5-[(4'-(N-imidazolyl)phenyl)aminocarbonyl]-3-trifluoromethyl-pyrazole

There total 4 articles about 1-(3-cyanophenyl)-5-[(4'-(N-imidazolyl)phenyl)aminocarbonyl]-3-trifluoromethyl-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 1-(3-cyanophenyl)-5-[(4'-(N-imidazolyl)phenyl)aminocarbonyl]-3-trifluoromethyl-pyrazole (209955-42-0)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylsulfoxide

2: H₂ / Pd / methanol

3: pyridine; DMAP / CH₂Cl₂

With pyridine; dmap; hydrogen; potassium carbonate; palladium; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2004.08.034

Reference yield:

1-(3-cyanophenyl)-3-trifluoromethylpyrazole-5-carboxylic acid (209917-93-1) + 1(3)H-imidazole-4-carboxylic acid anilide (13189-13-4) → 1-(3-cyanophenyl)-5-[(4'-(N-imidazolyl)phenyl)aminocarbonyl]-3-trifluoromethyl-pyrazole (209955-42-0)

Guidance literature:

Reference yield:

1-(3-cyanophenyl)-3-trifluoromethylpyrazole-5-carboxylic acid (209917-93-1) → 1-(3-cyanophenyl)-5-[(4'-(N-imidazolyl)phenyl)aminocarbonyl]-3-trifluoromethyl-pyrazole (209955-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: COCl₂; DMF / CH₂Cl₂

2: pyridine; DMAP / CH₂Cl₂

With pyridine; dmap; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.bmcl.2004.08.034

upstream raw materials:

4-(N-imidazolyl)aniline

4-Fluoronitrobenzene

1-(3-cyanophenyl)-3-trifluoromethylpyrazole-5-carboxylic acid

1⁽³⁾H-imidazole-4-carboxylic acid anilide