N-(2,2-dimethoxy-ethyl)-4-{2-[2-(4-hydroxy-2-oxo-2,3-dihydro-benzothiazol-7-yl)-ethylamino]-ethyl}-benzamide

Base Information

Chemical Name:N-(2,2-dimethoxy-ethyl)-4-{2-[2-(4-hydroxy-2-oxo-2,3-dihydro-benzothiazol-7-yl)-ethylamino]-ethyl}-benzamide
CAS No.:1046492-36-7
Molecular Formula:C₂₂H₂₇N₃O₅S
Molecular Weight:445.539
Hs Code.:

Synonyms:N-(2,2-dimethoxy-ethyl)-4-{2-[2-(4-hydroxy-2-oxo-2,3-dihydro-benzothiazol-7-yl)-ethylamino]-ethyl}-benzamide

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Chemical Property of N-(2,2-dimethoxy-ethyl)-4-{2-[2-(4-hydroxy-2-oxo-2,3-dihydro-benzothiazol-7-yl)-ethylamino]-ethyl}-benzamide

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Technology Process of N-(2,2-dimethoxy-ethyl)-4-{2-[2-(4-hydroxy-2-oxo-2,3-dihydro-benzothiazol-7-yl)-ethylamino]-ethyl}-benzamide

There total 6 articles about N-(2,2-dimethoxy-ethyl)-4-{2-[2-(4-hydroxy-2-oxo-2,3-dihydro-benzothiazol-7-yl)-ethylamino]-ethyl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₅N₃O₅S

: 1046492-36-7
N-(2,2-dimethoxy-ethyl)-4-{2-[2-(4-hydroxy-2-oxo-2,3-dihydro-benzothiazol-7-yl)-ethylamino]-ethyl}-benzamide

Guidance literature:: With sodium triacetoxyborohydride; water; In 1-methyl-pyrrolidin-2-one; acetic acid; at 20 ℃; for 0.5h;

Reference yield:

: 189012-93-9
7-(2-aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrochloride

: 1046492-34-5
N-(2,2-dimethoxyethyl)-4-(2-oxoethyl)benzamide

: 1046492-36-7
N-(2,2-dimethoxy-ethyl)-4-{2-[2-(4-hydroxy-2-oxo-2,3-dihydro-benzothiazol-7-yl)-ethylamino]-ethyl}-benzamide

Guidance literature:: 7-(2-aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrochloride; N-(2,2-dimethoxyethyl)-4-(2-oxoethyl)benzamide; With water; sodium tris(acetoxy)borohydride; acetic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; water; ethyl acetate;

Reference yield:

: 193418-22-3
4-(2-((tert-butyldimethylsilyl)oxy)ethyl)benzoic acid

: 1046492-36-7
N-(2,2-dimethoxy-ethyl)-4-{2-[2-(4-hydroxy-2-oxo-2,3-dihydro-benzothiazol-7-yl)-ethylamino]-ethyl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 1 h

2: N,N-dimethyl-formamide / 0.5 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h

4: Dess-Martin periodane / dichloromethane / 1 h

5: water; sodium tris(acetoxy)borohydride; acetic acid / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

With tetrabutyl ammonium fluoride; water; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;