1-[4-(2-oxo-2H-pyridin-1-ylmethyl)benzyl]-1H-[1,2,3]triazole-4-carboxylic acid 4-aminomethylbenzylamide hydrochloride

Base Information

Chemical Name:1-[4-(2-oxo-2H-pyridin-1-ylmethyl)benzyl]-1H-[1,2,3]triazole-4-carboxylic acid 4-aminomethylbenzylamide hydrochloride
CAS No.:1665276-15-2
Molecular Formula:C₂₄H₂₄N₆O₂*ClH
Molecular Weight:464.955
Hs Code.:

Synonyms:1-[4-(2-oxo-2H-pyridin-1-ylmethyl)benzyl]-1H-[1,2,3]triazole-4-carboxylic acid 4-aminomethylbenzylamide hydrochloride

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Chemical Property of 1-[4-(2-oxo-2H-pyridin-1-ylmethyl)benzyl]-1H-[1,2,3]triazole-4-carboxylic acid 4-aminomethylbenzylamide hydrochloride

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Technology Process of 1-[4-(2-oxo-2H-pyridin-1-ylmethyl)benzyl]-1H-[1,2,3]triazole-4-carboxylic acid 4-aminomethylbenzylamide hydrochloride

There total 7 articles about 1-[4-(2-oxo-2H-pyridin-1-ylmethyl)benzyl]-1H-[1,2,3]triazole-4-carboxylic acid 4-aminomethylbenzylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1618648-10-4
{4-[({1-[4-(2-oxo-2H-pyridin-1-ylmethyl)benzyl]-1H-[1,2,3]triazole-4-carbonyl}amino)-5-methyl]benzyl}carbamic acid tert-butyl ester

: 1665276-15-2
1-[4-(2-oxo-2H-pyridin-1-ylmethyl)benzyl]-1H-[1,2,3]triazole-4-carboxylic acid 4-aminomethylbenzylamide hydrochloride

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1564668-60-5
1-{[4-(hydroxymethyl)phenyl]methyl}-1,2-dihydropyridin-2-one

: 1665276-15-2
1-[4-(2-oxo-2H-pyridin-1-ylmethyl)benzyl]-1H-[1,2,3]triazole-4-carboxylic acid 4-aminomethylbenzylamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 18 h / 20 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 18 h / 50 °C / Inert atmosphere

4: benzotriazol-1-ol; triethylamine / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

5: water; hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; copper(ll) sulfate pentahydrate; diphenyl phosphoryl azide; water; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1618648-07-9
1-(4-azidomethylbenzyl)-1H-pyridin-2-one

: 1665276-15-2
1-[4-(2-oxo-2H-pyridin-1-ylmethyl)benzyl]-1H-[1,2,3]triazole-4-carboxylic acid 4-aminomethylbenzylamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 18 h / 20 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran / 18 h / 50 °C / Inert atmosphere

3: benzotriazol-1-ol; triethylamine / dichloromethane; N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

4: water; hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; copper(ll) sulfate pentahydrate; water; benzotriazol-1-ol; sodium L-ascorbate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;