cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethyl-piperidine-1-carboxylic acid 1-tert-butoxycarbonyl-azetidin-3-yl ester

Base Information

Chemical Name:cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethyl-piperidine-1-carboxylic acid 1-tert-butoxycarbonyl-azetidin-3-yl ester
CAS No.:1148130-36-2
Molecular Formula:C₃₅H₄₃F₆N₇O₄
Molecular Weight:739.761
Hs Code.:

cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethyl-piperidine-1-carboxylic acid 1-tert-butoxycarbonyl-azetidin-3-yl ester

Synonyms:cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethyl-piperidine-1-carboxylic acid 1-tert-butoxycarbonyl-azetidin-3-yl ester

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Chemical Property of cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethyl-piperidine-1-carboxylic acid 1-tert-butoxycarbonyl-azetidin-3-yl ester

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Technology Process of cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethyl-piperidine-1-carboxylic acid 1-tert-butoxycarbonyl-azetidin-3-yl ester

There total 1 articles about cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethyl-piperidine-1-carboxylic acid 1-tert-butoxycarbonyl-azetidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1009368-28-8
tert-butyl 3-((chlorocarbonyl)oxy)azetidine-1-carboxylate

: 1148129-95-6
N-(3,5-bis-(trifluoromethyl)benzyl)-N-((2R,4r,6S)-2,6-diethylpiperidin-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine

: 1148130-36-2
cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethyl-piperidine-1-carboxylic acid 1-tert-butoxycarbonyl-azetidin-3-yl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h;

Reference yield: 54.0%

: 1148130-36-2
cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethyl-piperidine-1-carboxylic acid 1-tert-butoxycarbonyl-azetidin-3-yl ester

: 96-32-2
bromoacetic acid methyl ester

: 1148129-48-9
cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethylpiperidine-1-carboxylic acid 1-methoxycarbonylmethyl-azetidin-3-yl ester

Guidance literature:: cis-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2,6-diethyl-piperidine-1-carboxylic acid 1-tert-butoxycarbonyl-azetidin-3-yl ester; With trifluoroacetic acid; In dichloromethane;

bromoacetic acid methyl ester; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 60 ℃; for 0.5h;