Technology Process of 1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-(3aS,9aS)-1H-benzindene-2(R),5-diol
There total 22 articles about 1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-(3aS,9aS)-1H-benzindene-2(R),5-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium; diphenylphosphane;
In
tetrahydrofuran; hexane;
at 70 ℃;
for 25h;
DOI:10.1021/jo00234a016
- Guidance literature:
-
With
n-butyllithium; diphenylphosphane;
In
tetrahydrofuran; hexane;
at 70 ℃;
for 25h;
DOI:10.1021/jo00234a016
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 96 percent / phosphorus tribromide / 3.75 h / 0 - 100 °C
2: 81 percent / n-butyllithium / tetrahydrofuran; hexane / 5 h / 20 - 60 °C
3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C to 0 deg C, 3 h
4: H2 / 10percent Pd/C / ethanol / 46 h / 2585.7 Torr / Ambient temperature
5: 93 percent / aq. sodium hydride, sodium borohydride / ethanol; CH2Cl2 / 2 h / -10 °C
6: 40 percent / triethylamine / toluene / 0.42 h
7: 100 percent / lithium aluminium hydride / tetrahydrofuran / 4 h / 60 - 65 °C
8: 94.5 percent / diphenylphosphine, n-butyllithium / tetrahydrofuran; hexane / 25 h / 70 °C
With
sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; hydrogen; phosphorus tribromide; sodium hydride; triethylamine; diphenylphosphane;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; toluene;
DOI:10.1021/jo00234a016
