2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-5-carboxylic acid isopropylamide

Base Information

Chemical Name:2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-5-carboxylic acid isopropylamide
CAS No.:1201674-13-6
Molecular Formula:C₂₄H₃₄N₆O
Molecular Weight:422.574
Hs Code.:

Synonyms:2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-5-carboxylic acid isopropylamide

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Chemical Property of 2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-5-carboxylic acid isopropylamide

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Technology Process of 2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-5-carboxylic acid isopropylamide

There total 6 articles about 2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-5-carboxylic acid isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1201674-12-5
2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-5-carboxylic acid

: 75-31-0
isopropylamine

: 1201674-13-6
2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-5-carboxylic acid isopropylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 96h;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1201674-13-6
2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-5-carboxylic acid isopropylamide

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / 72 h / 85 °C

2: triethylamine / tetrahydrofuran / 12 h / Reflux

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol; toluene / 16 h / 110 °C

4: dimethyl sulfoxide / 48 h / 100 °C

5: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

6: water; lithium hydroxide / tetrahydrofuran / 120 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 96 h / 20 °C

With sulfuric acid; water; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 3: Suzuki Coupling;

Reference yield:

: 1201675-60-6
4-(6-chloro-3-ethoxycarbonyl-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1201674-13-6
2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-5-carboxylic acid isopropylamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol; toluene / 16 h / 110 °C

2: dimethyl sulfoxide / 48 h / 100 °C

3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

4: water; lithium hydroxide / tetrahydrofuran / 120 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 96 h / 20 °C

With water; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1: Suzuki Coupling;