sulfuric acid 13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: sulfuric acid 13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 2,2,2-trichloro-ethyl ester
• CAS No.: 895632-76-5
• Molecular Formula: C₃₄H₃₀Cl₃NO₁₁S
• Molecular Weight: 767.037
• Mol file: 895632-76-5.mol

Synonyms:sulfuric acid 13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 2,2,2-trichloro-ethyl ester

Chemical Property of sulfuric acid 13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sulfuric acid 13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 2,2,2-trichloro-ethyl ester

There total 12 articles about sulfuric acid 13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one (895632-75-4) + chlorosulfuric acid 2,2,2-trichloroethyl ester (764-09-0) → sulfuric acid 13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 2,2,2-trichloro-ethyl ester (895632-76-5)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2006.03.121

Reference yield:

20-benzyl-13-isopropyllamellarin α (895632-67-4) → sulfuric acid 13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 2,2,2-trichloro-ethyl ester (895632-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / H₂ / Pd/C / ethyl acetate / 2 h / 20 °C

2: 96 percent / DMAP; Et₃N / tetrahydrofuran / 4 h / 20 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/j.tetlet.2006.03.121

Reference yield:

1-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-(3-isopropoxy-4-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester (895632-68-5) → sulfuric acid 13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester 2,2,2-trichloro-ethyl ester (895632-76-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 90 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 20 h / Heating

2.1: 93 percent / cc.HCl / methanol / 2 h / Heating

3.1: aq. KOH / ethanol / 3 h / Heating

3.2: 77 percent / p-TsOH / CH₂Cl₂ / 1 h / Heating

4.1: 96 percent / Cu₂O; quinoline / 0.17 h / 220 °C

5.1: 95 percent / phenyliodine bis(trifluoroacetate); BF₃*Et₂O / CH₂Cl₂ / 1.5 h / -40 °C

6.1: 99 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 30 h / Heating

7.1: 99 percent / H₂ / Pd/C / ethyl acetate / 2 h / 20 °C

8.1: 96 percent / DMAP; Et₃N / tetrahydrofuran / 4 h / 20 °C

With quinoline; copper(I) oxide; hydrogenchloride; dmap; potassium hydroxide; boron trifluoride diethyl etherate; hydrogen; sodium carbonate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-[(trifluoroacetoxy)iodo]benzene; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; 1.1: Suzuki-Miyaura coupling;

DOI:10.1016/j.tetlet.2006.03.121

upstream raw materials:

3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

chlorosulfuric acid 2,2,2-trichloroethyl ester

1-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-(3-isopropoxy-4-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

20-benzyl-13-isopropyllamellarin α

Downstream raw materials:

14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6-oxo-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-3-yl 2,2,2-trichloroethyl sulfate

Refernces