6-(4,4′-dimethoxytriphenylmethyloxy)hexyl 2-cyanoethyl-N,N-diisopropylphosphoramidite

Base Information

Chemical Name:6-(4,4′-dimethoxytriphenylmethyloxy)hexyl 2-cyanoethyl-N,N-diisopropylphosphoramidite
CAS No.:158041-82-8
Molecular Formula:C₃₆H₄₉N₂O₅P
Molecular Weight:620.769
Hs Code.:

Synonyms:6-(4,4′-dimethoxytriphenylmethyloxy)hexyl 2-cyanoethyl-N,N-diisopropylphosphoramidite

Suppliers and Price of 6-(4,4′-dimethoxytriphenylmethyloxy)hexyl 2-cyanoethyl-N,N-diisopropylphosphoramidite

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 6-(4,4′-dimethoxytriphenylmethyloxy)hexyl 2-cyanoethyl-N,N-diisopropylphosphoramidite

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 6-(4,4′-dimethoxytriphenylmethyloxy)hexyl 2-cyanoethyl-N,N-diisopropylphosphoramidite

There total 6 articles about 6-(4,4′-dimethoxytriphenylmethyloxy)hexyl 2-cyanoethyl-N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 6-(4,4′-dimethoxytriphenylmethyloxy)hexan-1-ol

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 158041-82-8
6-(4,4′-dimethoxytriphenylmethyloxy)hexyl 2-cyanoethyl-N,N-diisopropylphosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Molecular sieve; Inert atmosphere; Cooling with ice;
DOI:10.1021/acs.joc.0c02887

Reference yield: 68.0%

: 6-(4,4′-dimethoxytriphenylmethyloxy)hexan-1-ol

: 2-cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite

: 158041-82-8
6-(4,4′-dimethoxytriphenylmethyloxy)hexyl 2-cyanoethyl-N,N-diisopropylphosphoramidite

Guidance literature:: With 1H-tetrazole; In acetonitrile; at 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 629-11-8
1,6-hexanediol

: 158041-82-8
6-(4,4′-dimethoxytriphenylmethyloxy)hexyl 2-cyanoethyl-N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; tetrahydrofuran / 6 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Molecular sieve; Inert atmosphere; Cooling with ice

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1021/acs.joc.0c02887