3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-cyanophenyl)-2-oxophenoxadine

Base Information

Chemical Name:3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-cyanophenyl)-2-oxophenoxadine
CAS No.:1332507-62-6
Molecular Formula:C₄₄H₅₇N₅O₈Si₂
Molecular Weight:840.136
Hs Code.:

Synonyms:3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-cyanophenyl)-2-oxophenoxadine

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Chemical Property of 3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-cyanophenyl)-2-oxophenoxadine

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Technology Process of 3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-cyanophenyl)-2-oxophenoxadine

There total 12 articles about 3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-cyanophenyl)-2-oxophenoxadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1332507-58-0
3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-trifluoromethylsulfonyl-2-oxophenoxadine

: 126747-14-6
4-cyanophenylboronic acid

: 1332507-62-6
3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-cyanophenyl)-2-oxophenoxadine

Guidance literature:: With potassium phosphate; palladium diacetate; XPhos; In 1,4-dioxane; at 100 ℃; for 17h;
DOI:10.1016/j.tet.2011.03.111

Reference yield:

: 1332507-70-6
3',5'-di-O-tert-butyldimethylsilyl-N-[4-(2-N-benzylcarbamylethoxy-4,6-O-tert-butyldimethylsilylphenyl)]-2'-deoxy-5-bromouridine

: 1332507-62-6
3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-cyanophenyl)-2-oxophenoxadine

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; triethylamine / 47 h / 80 °C / Inert atmosphere

2: triethylamine / dichloromethane / 22 h / 20 °C / Inert atmosphere

3: potassium phosphate; palladium diacetate; XPhos / 1,4-dioxane / 17 h / 100 °C

With methanol; potassium phosphate; palladium diacetate; triethylamine; XPhos; In 1,4-dioxane; dichloromethane; 3: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2011.03.111

Reference yield:

: 1332507-57-9
3-(3',5'-di-O-tert-butyldimethylsilyl-d-ribofuranosyl)-9-(2-N-benzylcarbamylethoxy)-1,3-diaza-7-hydroxy-2-oxophenoxadine

: 1332507-62-6
3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-cyanophenyl)-2-oxophenoxadine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 22 h / 20 °C / Inert atmosphere

2: potassium phosphate; palladium diacetate; XPhos / 1,4-dioxane / 17 h / 100 °C

With potassium phosphate; palladium diacetate; triethylamine; XPhos; In 1,4-dioxane; dichloromethane; 2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2011.03.111