(4bR,6aR,8R,10S,10aS,10bS)-2-Allyloxy-10-benzyloxymethoxy-8-(dimethyl-phenyl-silanyl)-10a-methyl-6,6a,7,8,9,10,10a,10b,11,12-decahydro-4bH-chrysen-5-one

Base Information

Chemical Name:(4bR,6aR,8R,10S,10aS,10bS)-2-Allyloxy-10-benzyloxymethoxy-8-(dimethyl-phenyl-silanyl)-10a-methyl-6,6a,7,8,9,10,10a,10b,11,12-decahydro-4bH-chrysen-5-one
CAS No.:303998-62-1
Molecular Formula:C₃₈H₄₆O₄Si
Molecular Weight:594.866
Hs Code.:

(4bR,6aR,8R,10S,10aS,10bS)-2-Allyloxy-10-benzyloxymethoxy-8-(dimethyl-phenyl-silanyl)-10a-methyl-6,6a,7,8,9,10,10a,10b,11,12-decahydro-4bH-chrysen-5-one

Synonyms:(4bR,6aR,8R,10S,10aS,10bS)-2-Allyloxy-10-benzyloxymethoxy-8-(dimethyl-phenyl-silanyl)-10a-methyl-6,6a,7,8,9,10,10a,10b,11,12-decahydro-4bH-chrysen-5-one

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Chemical Property of (4bR,6aR,8R,10S,10aS,10bS)-2-Allyloxy-10-benzyloxymethoxy-8-(dimethyl-phenyl-silanyl)-10a-methyl-6,6a,7,8,9,10,10a,10b,11,12-decahydro-4bH-chrysen-5-one

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Technology Process of (4bR,6aR,8R,10S,10aS,10bS)-2-Allyloxy-10-benzyloxymethoxy-8-(dimethyl-phenyl-silanyl)-10a-methyl-6,6a,7,8,9,10,10a,10b,11,12-decahydro-4bH-chrysen-5-one

There total 4 articles about (4bR,6aR,8R,10S,10aS,10bS)-2-Allyloxy-10-benzyloxymethoxy-8-(dimethyl-phenyl-silanyl)-10a-methyl-6,6a,7,8,9,10,10a,10b,11,12-decahydro-4bH-chrysen-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 303998-23-4
(2R,4S,4aS,4bR,12aR)-8-Allyloxy-4-benzyloxymethoxy-2-(dimethyl-phenyl-silanyl)-4a-methyl-11-triethylsilanyloxy-1,2,3,4,4a,4b,5,6,12,12a-decahydro-chrysene

: 303998-62-1
(4bR,6aR,8R,10S,10aS,10bS)-2-Allyloxy-10-benzyloxymethoxy-8-(dimethyl-phenyl-silanyl)-10a-methyl-6,6a,7,8,9,10,10a,10b,11,12-decahydro-4bH-chrysen-5-one

Guidance literature:: With toluene-4-sulfonic acid; In methanol; dichloromethane; at 23 ℃; for 0.0833333h;
DOI:10.1021/ja0024892

Reference yield:

: (2R,4bR)-8-Allyloxy-2-(dimethyl-phenyl-silanyl)-4a-methyl-11-triethylsilanyloxy-2,3,4a,4b,5,6,12,12a-octahydro-1H-chrysen-4-one

: 303998-62-1
(4bR,6aR,8R,10S,10aS,10bS)-2-Allyloxy-10-benzyloxymethoxy-8-(dimethyl-phenyl-silanyl)-10a-methyl-6,6a,7,8,9,10,10a,10b,11,12-decahydro-4bH-chrysen-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / LiAlH₄ / diethyl ether / 0.5 h / -78 °C

2: 92 percent / i-Pr₂NEt / CH₂Cl₂ / 46 h / 23 °C

3: 89 percent / p-TsOH / CH₂Cl₂; methanol / 0.08 h / 23 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja0024892

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 303998-62-1
(4bR,6aR,8R,10S,10aS,10bS)-2-Allyloxy-10-benzyloxymethoxy-8-(dimethyl-phenyl-silanyl)-10a-methyl-6,6a,7,8,9,10,10a,10b,11,12-decahydro-4bH-chrysen-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / i-Pr₂NEt / CH₂Cl₂ / 46 h / 23 °C

2: 89 percent / p-TsOH / CH₂Cl₂; methanol / 0.08 h / 23 °C

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/ja0024892