Methylprednisolone hemisuccinate

Base Information

• Chemical Name: Methylprednisolone hemisuccinate
• CAS No.: 2921-57-5
• Molecular Formula: C26H34O8
• Molecular Weight: 474.551
• Hs Code.: 2937290000
• European Community (EC) Number: 220-863-9
• UNII: 5GMR90S4KN
• DSSTox Substance ID: DTXSID80183466
• Nikkaji Number: J7.938C
• Wikipedia: Methylprednisolone_succinate
• NCI Thesaurus Code: C87234
• Pharos Ligand ID: 32HVLB7WC53U
• Metabolomics Workbench ID: 155004
• ChEMBL ID: CHEMBL1201265
• Mol file: 2921-57-5.mol

Synonyms:6 alpha-Methylprednisolone Sodium Hemisuccinate;A-MethaPred;Hemisuccinate, Methylprednisolone;Methylprednisolone Hemisuccinate;Methylprednisolone Hemisuccinate Monosodium Salt;Methylprednisolone Sodium Hemisuccinate;Methylprednisolone Sodium Succinate;Methylprednisolone Succinate;Sodium Hemisuccinate, Methylprednisolone;Sodium Succinate, Methylprednisolone;Solu-Medrol;Solumedrol;Succinate, Methylprednisolone;Urbason-Soluble;UrbasonSoluble

Chemical Property of Methylprednisolone hemisuccinate

Chemical Property:

• Vapor Pressure: 5.28E-22mmHg at 25°C
• Refractive Index: 1.593
• Boiling Point: 689.6 °C at 760 mmHg
• PKA: 4.29±0.17(Predicted)
• Flash Point: 230.7 °C
• PSA: 138.20000
• Density: 1.33 g/cm³
• LogP: 2.21930
• Storage Temp.: 2-8°C
• Solubility.: Practically insoluble in water, slightly soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 474.22536804
• Heavy Atom Count: 34
• Complexity: 981

Purity/Quality:

99.9% ^*data from raw suppliers

6α-Methylprednisolone21-Hemisuccinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O
• Isomeric SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O
• Recent ClinicalTrials: Effect of Intravenous Methylprednisolone and Intravenous Erythropoietin in Toxic Optic Neuropathies: Randomized Clinical Trial.
• Recent EU Clinical Trials: The effect of corticosteroids on early recovery after major surgery in elderly patients_
• Description: Methylprednisolone hemisuccinate is a glucocorticoid used to treat severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal disorders, and endocrine disorders, among others.
• Uses: 6α-Methylprednisolone 21-Hemisuccinate is a derivative of methylprednisolone (M325934), a glucocorticoid and a anti-inflammatory drug used to treat central nervous system disorders such as multiple sclerosis. 6α-Methylprednisolone 21-Hemisuccinate was examined for potential therapeutic efficacy in a model of neuroinflammation in rats with acute autoimmune encephalomyelitis. Glucocorticoid.

Technology Process of Methylprednisolone hemisuccinate

There total 2 articles about Methylprednisolone hemisuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6α-methylprednisolone 17-hemisuccinate (77074-42-1) → Methylprednisolone (83-43-2) + 6α-methylprednisolone-21-hydrogen succinate (2921-57-5)

Guidance literature:

With aq. buffer; In N,N-dimethyl-formamide; at 25 ℃; Rate constant; Mechanism; pH dependence;

DOI:10.1002/jps.2600730507

Reference yield:

6α-methylprednisolone 17-hemisuccinate (77074-42-1) → 6α-methylprednisolone-21-hydrogen succinate (2921-57-5)

Guidance literature:

In water; at 25 ℃; Rate constant;

DOI:10.1002/jps.2600700217

Reference yield:

6α-methylprednisolone-21-hydrogen succinate (2921-57-5) → 6α-methylprednisolone 17-hemisuccinate (77074-42-1)

Guidance literature:

With water; In acetonitrile; at 25 ℃; Rate constant;

DOI:10.1002/jps.2600720431

upstream raw materials:

6α-methylprednisolone 17-hemisuccinate

Downstream raw materials:

Methylprednisolone

6α-methylprednisolone 17-hemisuccinate

Refernces

• 1、 Anderson,Conradi,Lambert. "Carboxyl group catalysis of acyl transfer reactions in corticosteroid 17- and 21-monoesters". . p. 604 - 610. Retrieved 2007/10/02.