(±)-ethyl 2-(benzylcarbamoyl)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate

Base Information

Chemical Name:(±)-ethyl 2-(benzylcarbamoyl)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate
CAS No.:1405680-08-1
Molecular Formula:C₁₆H₂₀N₂O₃
Molecular Weight:288.346
Hs Code.:

Synonyms:(±)-ethyl 2-(benzylcarbamoyl)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate

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Chemical Property of (±)-ethyl 2-(benzylcarbamoyl)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate

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Technology Process of (±)-ethyl 2-(benzylcarbamoyl)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate

There total 4 articles about (±)-ethyl 2-(benzylcarbamoyl)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1405679-98-2
(±)-ethyl 2-(benzylcarbamoyl)-5-(tosyloxyimino)hexanoate

: 1405680-08-1
(±)-ethyl 2-(benzylcarbamoyl)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate

Guidance literature:: With caesium carbonate; In dichloromethane; for 0.5h; Reflux;
DOI:10.1039/c2ob26423d

Reference yield:

: 29689-63-2
ethyl (N-benzylcarbamoyl)acetate

: 1405680-08-1
(±)-ethyl 2-(benzylcarbamoyl)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dichloromethane / 20 °C

2: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / Reflux

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: caesium carbonate / dichloromethane / 0.5 h / Reflux

With hydroxylamine hydrochloride; potassium carbonate; caesium carbonate; triethylamine; In ethanol; dichloromethane; 1: |Michael Addition;
DOI:10.1039/c2ob26423d

Reference yield:

: 1405679-59-5
(±)-ethyl 2-(benzylcarbamoyl)-5-oxohexanoate

: 1405680-08-1
(±)-ethyl 2-(benzylcarbamoyl)-5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / Reflux

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: caesium carbonate / dichloromethane / 0.5 h / Reflux

With hydroxylamine hydrochloride; caesium carbonate; triethylamine; In ethanol; dichloromethane;
DOI:10.1039/c2ob26423d