4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline

Base Information

• Chemical Name: 4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline
• CAS No.: 28200-70-6
• Molecular Formula: C₁₉H₂₂N₂O₃
• Molecular Weight: 326.395
• Mol file: 28200-70-6.mol

Synonyms:4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline

Chemical Property of 4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline

There total 5 articles about 4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(5-methoxy-2-nitro-benzyl)-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolinium; iodide (110571-76-1) → 4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline (28200-70-6)

Guidance literature:

With hydrogenchloride; zinc;

DOI:10.1021/ja01235a021

Reference yield:

5-(5-methoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline (28200-69-3) → 4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline (28200-70-6)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol;

Reference yield:

5-methoxy-2-nitrotoluene (5367-32-8) → 4-methoxy-2-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-aniline (28200-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOEt / ethanol / Heating

2: H₂ / PtO₂ / methanol

With hydrogen; sodium ethanolate; platinum(IV) oxide; In methanol; ethanol;

upstream raw materials:

5-(5-methoxy-2-nitro-benzyl)-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolinium; iodide

5-(5-methoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

5-methoxy-2-nitrotoluene

6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide

Downstream raw materials:

N-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline

5-methoxy-1H-indazole

10-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline