8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine

Base Information

• Chemical Name: 8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine
• CAS No.: 1578244-55-9
• Molecular Formula: C₁₈H₁₅ClN₆O
• Molecular Weight: 366.81
• Mol file: 1578244-55-9.mol

Synonyms:8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine

Chemical Property of 8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine

There total 8 articles about 8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

8-chloro-2-(methylsulfonyl)pyrido[3,4-d]pyrimidine (1578246-63-5) + N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)formamide (1578246-27-1) → 8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine (1578244-55-9)

Guidance literature:

N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)formamide; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.333333h;

8-chloro-2-(methylsulfonyl)pyrido[3,4-d]pyrimidine; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

With water; sodium hydroxide; In tetrahydrofuran; methanol; for 1h;

Reference yield:

8-chloro-2-(methylsulfanyl)pyrido[3,4-d]pyrimidine (1578245-95-0) → 8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine (1578244-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 - 20 °C

2.2: 18 h / 0 - 20 °C

2.3: 1 h

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

2-(methylsulfanyl)-7H,8H-pyrido[3,4-d]pyrimidin-8-one (1578245-94-9) → 8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine (1578244-55-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 18 h / 70 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 - 20 °C

3.2: 18 h / 0 - 20 °C

3.3: 1 h

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

8-chloro-2-(methylsulfonyl)pyrido[3,4-d]pyrimidine

N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)formamide

5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid

methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate

Downstream raw materials:

N-(2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenylamino)pyrido[3,4-d]pyrimidin-8-yl)-2-methylpropane-2-sulfonamide

N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N₈,N₈-dimethylpyrido[3,4-d]pyrimidine-2,8-diamine

N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N₈-methylpyrido[3,4-d]pyrimidine-2,8-diamine

N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N₈-(oxetan-3-yl)pyrido[3,4-d]pyrimidine-2,8-diamine