Multi-step reaction with 5 steps
1: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
2: diethyl ether / 0 - 20 °C / Inert atmosphere
3: 4 h / 20 °C / Inert atmosphere
4: tris-(dibenzylideneacetone)dipalladium(0); (11aR)-(+)-10,11,12,13-tetrahydrodiindeno-[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine; sodium t-butanolate / toluene / 14 h / 20 - 90 °C / Inert atmosphere
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); (11aR)-(+)-10,11,12,13-tetrahydrodiindeno-[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine; tetrabutyl ammonium fluoride; pyridinium chlorochromate; sodium t-butanolate;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1021/ol2009895