((2R,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)methanol

Base Information

Chemical Name:((2R,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)methanol
CAS No.:1610033-59-4
Molecular Formula:C₂₅H₃₃FN₂O₄
Molecular Weight:444.546
Hs Code.:

Synonyms:((2R,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)methanol

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Chemical Property of ((2R,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)methanol

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Technology Process of ((2R,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)methanol

There total 6 articles about ((2R,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: (3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-4-(4-iodophenoxy)-3-methylpiperidine

: ((2R,4R)-4-methoxypyrrolidin-2-yl)methanol hydrochloride

: 1610033-59-4
((2R,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)methanol

Guidance literature:: With copper(l) iodide; sodium hydroxide; In butan-1-ol; at 90 ℃;

Reference yield:

: 2-bromo-1-fluoro-4-methoxy-benzene

: 1610033-59-4
((2R,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane / tetrahydrofuran / 70 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 - 20 °C

2.2: 1.5 h / 50 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 55 °C

4.1: sodium nitrite; potassium iodide; toluene-4-sulfonic acid / water; acetonitrile / 1 h / 0 - 20 °C

5.1: sodium hydroxide; copper(l) iodide / butan-1-ol / 90 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; hydrogen; sodium hydride; toluene-4-sulfonic acid; potassium iodide; sodium hydroxide; lithium hexamethyldisilazane; sodium nitrite; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; butan-1-ol;

Reference yield:

: (3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-ol

: 1610033-59-4
((2R,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 - 20 °C

1.2: 1.5 h / 50 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 55 °C

3.1: sodium nitrite; potassium iodide; toluene-4-sulfonic acid / water; acetonitrile / 1 h / 0 - 20 °C

4.1: sodium hydroxide; copper(l) iodide / butan-1-ol / 90 °C

With copper(l) iodide; palladium 10% on activated carbon; hydrogen; sodium hydride; toluene-4-sulfonic acid; potassium iodide; sodium hydroxide; sodium nitrite; In methanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; butan-1-ol;