(S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester

Base Information

• Chemical Name: (S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester
• CAS No.: 1221593-80-1
• Molecular Formula: C₂₅H₂₉N₃O₅
• Molecular Weight: 451.522
• Mol file: 1221593-80-1.mol

Synonyms:(S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester

Chemical Property of (S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester

There total 5 articles about (S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Boc-Glu(OBzl)-OH (13574-13-5) + 4-cyanobenzylamine hydrochloride (15996-76-6) → (S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester (1221593-80-1)

Guidance literature:

Boc-Glu(OBzl)-OH; With benzotriazole-1-yl-oxy-tris-(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

4-cyanobenzylamine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield: 100.0%

4-(aminomethyl)benzonitrile hydrochloride + Boc-Glu(OBzl)-OH (13574-13-5) → (S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester (1221593-80-1)

Guidance literature:

Boc-Glu(OBzl)-OH; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

4-(aminomethyl)benzonitrile hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield: 100.0%

4-(aminomethyl)benzonitrile hydrochloride + Boc-Glu(OBzl)-OH (13574-13-5) → (S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester (1221593-80-1)

Guidance literature:

Boc-Glu(OBzl)-OH; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

4-(aminomethyl)benzonitrile hydrochloride; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 1h;

upstream raw materials:

5-(benzyloxy)-2-(tert-butoxycarbonylamino)-5-oxopentanoic acid

4-cyanobenzylamine hydrochloride

Boc-Glu(OBzl)-OH

N-Boc-L-β-glutamic acid 5-benzyl ester

Downstream raw materials:

(S)-4-tert-butoxycarbonylamino-4-[4-(N-hydroxycarbamimidoyl)-benzyl carbamoyl]-butyric acid benzyl ester

(S)-4-tert-butoxycarbonylamino-4-[ 4-(N-acetylhydroxycarbamimidoyl)-benzyl carbamoyl]-butyric acid benzyl ester

(S)-4-[4-(N-acetylhydroxycarbaininiidoyl)-benzylcarbamoyl]-4-((R)-4-phenyl-2-phenylmethanesulfonylamino-butyrylamino)-butyric acid benzyl ester

(S,Z)-benzyl 4-(tert-butoxycarbonylamino)-5-(4-(N'-hydroxycarbamimidoyl)benzylamino)-5-oxopentanoate