Toluene-4-sulfonic acid (R)-2-((1S,3R,5R,7S)-5-ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-1-methyl-ethyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (R)-2-((1S,3R,5R,7S)-5-ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-1-methyl-ethyl ester
CAS No.:80795-31-9
Molecular Formula:C₂₀H₃₀O₅S
Molecular Weight:382.521
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (R)-2-((1S,3R,5R,7S)-5-ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-1-methyl-ethyl ester

Suppliers and Price of Toluene-4-sulfonic acid (R)-2-((1S,3R,5R,7S)-5-ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-1-methyl-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Toluene-4-sulfonic acid (R)-2-((1S,3R,5R,7S)-5-ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-1-methyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid (R)-2-((1S,3R,5R,7S)-5-ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-1-methyl-ethyl ester

There total 12 articles about Toluene-4-sulfonic acid (R)-2-((1S,3R,5R,7S)-5-ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1470-83-3
lithium tosylate

: 80765-01-1
(S)-1-((1S,3R,5R,7S)-5-Ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-propan-2-ol

: 80795-31-9
Toluene-4-sulfonic acid (R)-2-((1S,3R,5R,7S)-5-ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-1-methyl-ethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/ja00370a071

Reference yield:

: 80764-96-1
(Z)-8-Hydroxy-5-methyl-non-5-enoic acid

: 80795-31-9
Toluene-4-sulfonic acid (R)-2-((1S,3R,5R,7S)-5-ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 20 percent

2: LiNiPr₂ / tetrahydrofuran

3: NaIO₄ / methanol

4: 92 percent / -78 °C

5: 1.) KOH, MeOH, 2.) KI₃, NaHCO₃ / 1.) H₂O

6: 1.) KOH, 2.) HCl / 1.) H₂O

7: 69 percent / CHCl₃ / 6 h / -30 °C

8: 52 percent / triphenylphosphine, diethylazodicarboxylate / tetrahydrofuran

With hydrogenchloride; methanol; potassium hydroxide; sodium periodate; potassium triiodide; sodium hydrogencarbonate; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/ja00370a071

Reference yield:

: 80764-93-8
(3Z,6Z)-6,9-Dimethyl-8,9-dihydro-5H-oxonin-2-one

: 80795-31-9
Toluene-4-sulfonic acid (R)-2-((1S,3R,5R,7S)-5-ethyl-1,3-dimethyl-6,8-dioxa-bicyclo[3.2.1]oct-7-yl)-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / -78 °C

2: 1.) KOH, MeOH, 2.) KI₃, NaHCO₃ / 1.) H₂O

3: 1.) KOH, 2.) HCl / 1.) H₂O

4: 69 percent / CHCl₃ / 6 h / -30 °C

5: 52 percent / triphenylphosphine, diethylazodicarboxylate / tetrahydrofuran

With hydrogenchloride; methanol; potassium hydroxide; potassium triiodide; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; chloroform;
DOI:10.1021/ja00370a071