2-[N-tert-butoxycarbonyl-2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylpropanamide

Base Information

• Chemical Name: 2-[N-tert-butoxycarbonyl-2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylpropanamide
• CAS No.: 1417442-67-1
• Molecular Formula: C₂₂H₃₄F₂N₂O₄
• Molecular Weight: 428.52
• Mol file: 1417442-67-1.mol

Synonyms:2-[N-tert-butoxycarbonyl-2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylpropanamide

Chemical Property of 2-[N-tert-butoxycarbonyl-2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[N-tert-butoxycarbonyl-2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylpropanamide

There total 6 articles about 2-[N-tert-butoxycarbonyl-2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-(tert-butoxycarbonyl)-2,2-difluoro-2-(3-butoxyphenyl)ethylamine (1417442-65-9) + 2-chloro-N,N-dimethyl-propionamide (10397-68-9,152786-29-3) → 2-[N-tert-butoxycarbonyl-2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylpropanamide (1417442-67-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

2,2-difluoro-[2-(-3-methoxphenyl)]acetonitrile (1417442-63-7) → 2-[N-tert-butoxycarbonyl-2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylpropanamide (1417442-67-1)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride; lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2: triethylamine / tetrahydrofuran / 24 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

2,2-difluoro-2-(3-butoxyphenyl)ethylamine (1417442-64-8) → 2-[N-tert-butoxycarbonyl-2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylpropanamide (1417442-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 24 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

2,2-difluoro-[2-(-3-methoxphenyl)]acetonitrile

2,2-difluoro-2-(3-butoxyphenyl)ethylamine

N-(tert-butoxycarbonyl)-2,2-difluoro-2-(3-butoxyphenyl)ethylamine

2-chloro-N,N-dimethyl-propionamide

Downstream raw materials:

2-[2,2-difluoro-2-(3-butoxyphenyl)-ethylamino]-N,N-dimethyl-propanamide