4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)benzonitrile

Base Information

Chemical Name:4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)benzonitrile
CAS No.:1416733-31-7
Molecular Formula:C₂₃H₁₆F₄N₆O₂
Molecular Weight:484.413
Hs Code.:

Synonyms:4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)benzonitrile

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Chemical Property of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)benzonitrile

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Technology Process of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)benzonitrile

There total 7 articles about 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 288-94-8
1H-tetrazole

: 1416733-36-2
C₂₂H₁₄F₄N₂O₂

: 1416733-32-8
4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(2H-tetrazol-2-yl)propyl)pyridin-3-yl)methoxy)benzonitrile

: 1416733-31-7
4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)benzonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 65 ℃; Inert atmosphere;

Reference yield:

: 101990-45-8
2-bromo-5-bromomethylpyridine

: 1416733-32-8
4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(2H-tetrazol-2-yl)propyl)pyridin-3-yl)methoxy)benzonitrile

: 1416733-31-7
4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: copper / dimethyl sulfoxide / 1 h / 20 °C

2.2: 16 h / 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C

4.1: diethyl ether / -5 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

With n-butyllithium; copper; potassium carbonate; caesium carbonate; In diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1416733-32-8
4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(2H-tetrazol-2-yl)propyl)pyridin-3-yl)methoxy)benzonitrile

: 1416733-31-7
4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)methoxy)benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate; methanol / 0 °C

2.1: phosphorus tribromide / diethyl ether / 1 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

4.1: copper / dimethyl sulfoxide / 1 h / 20 °C

4.2: 16 h / 20 °C

5.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

5.2: 2 h / -78 °C

6.1: diethyl ether / -5 - 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; n-butyllithium; phosphorus tribromide; copper; potassium carbonate; caesium carbonate; In diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;