(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

Base Information

Chemical Name:(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide
CAS No.:1382859-57-5
Molecular Formula:C₂₄H₂₆BrN₃O₃
Molecular Weight:484.393
Hs Code.:

Synonyms:(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

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Chemical Property of (S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

Chemical Property:

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Technology Process of (S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

There total 5 articles about (S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382859-68-8
(+/-)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

: 1382859-58-6
(R)-(-)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

: 1382859-57-5
(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

Guidance literature:: With Lux Amylose-2; In hexane; isopropyl alcohol; at 40 ℃; Resolution of racemate;
DOI:10.1016/j.bmc.2012.04.043

Reference yield:

: 116-53-0,600-07-7
2-Methylbutanoic acid

: 1382859-58-6
(R)-(-)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

: 1382859-57-5
(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / tetrachloromethane

2: thionyl chloride / dichloromethane / 4 h / 40 °C

3: tetrahydrofuran / 4 h / 20 °C

4: potassium carbonate / acetonitrile / Reflux

5: Lux Amylose-2.(R). / hexane; isopropyl alcohol / 40 °C / Resolution of racemate

With N-Bromosuccinimide; thionyl chloride; potassium carbonate; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmc.2012.04.043

Reference yield:

: 89180-37-0
2-bromo-2-methyl-butyryl chloride

: 1382859-58-6
(R)-(-)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

: 1382859-57-5
(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-2-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 4 h / 20 °C

2: potassium carbonate / acetonitrile / Reflux

3: Lux Amylose-2.(R). / hexane; isopropyl alcohol / 40 °C / Resolution of racemate

With potassium carbonate; In tetrahydrofuran; hexane; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmc.2012.04.043