{1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 10H-phenothiazin-10-ylacetate

Base Information

Chemical Name:{1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 10H-phenothiazin-10-ylacetate
CAS No.:1390635-98-9
Molecular Formula:C₂₆H₁₉N₅O₃S
Molecular Weight:481.535
Hs Code.:

Synonyms:{1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 10H-phenothiazin-10-ylacetate

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Chemical Property of {1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 10H-phenothiazin-10-ylacetate

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Technology Process of {1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 10H-phenothiazin-10-ylacetate

There total 4 articles about {1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 10H-phenothiazin-10-ylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1390636-00-6
prop-2-ynyl (10H-phenothiazin-10-yl)acetate

: 622787-69-3
2-azido-1-(4'-cyanophenyl)ethanone

: 1390635-98-9
{1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 10H-phenothiazin-10-ylacetate

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In methanol; water; acetonitrile; tert-butyl alcohol; at 50 ℃; for 24h;
DOI:10.1016/j.bmcl.2012.06.007

Reference yield:

: 1-[(10H-phenothiazin-10-ylacetyl)oxy]pyrrolidine-2,5-dione

: 1390635-98-9
{1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 10H-phenothiazin-10-ylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

2: copper(II) sulfate; sodium L-ascorbate / methanol; water; acetonitrile; tert-butyl alcohol / 24 h / 50 °C

With copper(II) sulfate; sodium L-ascorbate; triethylamine; In methanol; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2012.06.007

Reference yield:

: 25244-68-2
2-(10H-phenothiazin-10-yl)acetic acid

: 1390635-98-9
{1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 10H-phenothiazin-10-ylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

3: copper(II) sulfate; sodium L-ascorbate / methanol; water; acetonitrile; tert-butyl alcohol / 24 h / 50 °C

With copper(II) sulfate; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2012.06.007