Technology Process of 1-((2R,3S)-tetrahydro-2-phenylfuran-3-yl)ethanone
There total 7 articles about 1-((2R,3S)-tetrahydro-2-phenylfuran-3-yl)ethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulfuric acid; mercury(II) oxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 1h;
DOI:10.1021/ol302669q
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: vinyl acetate / hexane / 65 h / 20 °C / Molecular sieve; Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0.08 h / -15 °C / Inert atmosphere
2.2: 16 h / 20 °C
3.1: p-toluenesulfonic acid monohydrate / ethanol / 3 h / 20 °C
4.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 21 h / 0 - 20 °C
6.1: mercury(II) oxide; sulfuric acid / tetrahydrofuran; water / 1 h / 20 °C
With
vinyl acetate; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; p-toluenesulfonic acid monohydrate; tetrabutyl ammonium fluoride; triphenylphosphine; mercury(II) oxide; diethylazodicarboxylate;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene;
DOI:10.1021/ol302669q
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0.08 h / -15 °C / Inert atmosphere
1.2: 16 h / 20 °C
2.1: p-toluenesulfonic acid monohydrate / ethanol / 3 h / 20 °C
3.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 21 h / 0 - 20 °C
5.1: mercury(II) oxide; sulfuric acid / tetrahydrofuran; water / 1 h / 20 °C
With
trimethylsilyl trifluoromethanesulfonate; sulfuric acid; p-toluenesulfonic acid monohydrate; tetrabutyl ammonium fluoride; triphenylphosphine; mercury(II) oxide; diethylazodicarboxylate;
In
tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/ol302669q
