Technology Process of (2-fluoro-4-pentylphenyl)boronic acid
There total 6 articles about (2-fluoro-4-pentylphenyl)boronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-fluoro-3-pentylbenzene;
With
sec.-butyllithium;
In
tetrahydrofuran;
at -78 - 70 ℃;
for 2h;
Inert atmosphere;
tri-n-propyl borate;
In
tetrahydrofuran;
at -78 - 20 ℃;
With
hydrogenchloride;
In
water;
DOI:10.1039/c3tc31461h
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: iodine; magnesium / tetrahydrofuran / 2 h / Inert atmosphere; Reflux
1.2: -78 - 20 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / toluene / Reflux
3.1: palladium 10% on activated carbon; hydrogen; acetic acid / ethyl acetate
4.1: sec.-butyllithium / tetrahydrofuran / 2 h / -78 - 70 °C / Inert atmosphere
4.2: -78 - 20 °C
With
palladium 10% on activated carbon; hydrogen; iodine; sec.-butyllithium; toluene-4-sulfonic acid; magnesium; acetic acid;
In
tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1039/c3tc31461h
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; hydrogen; acetic acid / ethyl acetate
2.1: sec.-butyllithium / tetrahydrofuran / 2 h / -78 - 70 °C / Inert atmosphere
2.2: -78 - 20 °C
With
palladium 10% on activated carbon; hydrogen; sec.-butyllithium; acetic acid;
In
tetrahydrofuran; ethyl acetate;
DOI:10.1039/c3tc31461h
