methyl 3-{4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxo-6-[(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-1,2-oxazin-3-yl}propanoate

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Chemical Name:methyl 3-{4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxo-6-[(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-1,2-oxazin-3-yl}propanoate
CAS No.:1381847-54-6
Molecular Formula:C₃₂H₄₁NO₇
Molecular Weight:551.68
Hs Code.:

Synonyms:methyl 3-{4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxo-6-[(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-1,2-oxazin-3-yl}propanoate

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Chemical Property of methyl 3-{4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxo-6-[(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-1,2-oxazin-3-yl}propanoate

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Technology Process of methyl 3-{4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxo-6-[(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-1,2-oxazin-3-yl}propanoate

There total 2 articles about methyl 3-{4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxo-6-[(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-1,2-oxazin-3-yl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381847-51-3
methyl (4E)-5-[3-(cyclopentyloxy)-4-methoxyphenyl]-4-nitropent-4-enoate

: (+)-(1R,2S)-trans-phenylcyclohexanol vinyl ether

: 1381847-54-6
methyl 3-{4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxo-6-[(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-1,2-oxazin-3-yl}propanoate

Guidance literature:: With tin(IV) chloride; In dichloromethane; at -94 ℃; for 0.25h; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo300955n

Reference yield:

: 13013-02-0
methyl 4-nitrobutyrate

: 1381847-54-6
methyl 3-{4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxo-6-[(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-1,2-oxazin-3-yl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-butylamine / toluene / 14 h / Reflux

2: tin(IV) chloride / dichloromethane / 0.25 h / -94 °C / Inert atmosphere

With tin(IV) chloride; N-butylamine; In dichloromethane; toluene;
DOI:10.1021/jo300955n

Reference yield: 66.0%

: 1381847-54-6
methyl 3-{4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-oxo-6-[(2-phenylcyclohexyl)oxy]-5,6-dihydro-4H-1,2-oxazin-3-yl}propanoate

: 1253858-52-4
(7S,7aS)-7-[3-(cyclopentyloxy)-4-(methyloxy)phenyl]hexahydro-3H-pyrrolizin-3-one

: 34281-92-0
(1S,2R)-trans-2-phenyl-1-cyclohexanol

Guidance literature:: With platinum(IV) oxide; hydrogen; acetic acid; at 60 ℃; for 4h; under 15001.5 Torr; optical yield given as %de; Autoclave;
DOI:10.1021/jo300955n