Technology Process of 4-fluoro-4-(2-chlorophenyl)piperidine-1-sulfonamide
There total 6 articles about 4-fluoro-4-(2-chlorophenyl)piperidine-1-sulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; ethyl acetate;
for 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran; hexane / 0.5 h / -70 °C / Inert atmosphere
1.2: 0.5 h / Inert atmosphere
2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 4 h / -70 - 20 °C / Inert atmosphere
3.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 4 h
4.1: triethylamine / dichloromethane / 4 h / 3 - 20 °C
5.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 16 h
With
hydrogenchloride; isopropylmagnesium chloride; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 4 h / -70 - 20 °C / Inert atmosphere
2: hydrogenchloride / ethyl acetate; 1,4-dioxane / 4 h
3: triethylamine / dichloromethane / 4 h / 3 - 20 °C
4: hydrogenchloride / ethyl acetate; 1,4-dioxane / 16 h
With
hydrogenchloride; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
1,4-dioxane; dichloromethane; ethyl acetate;
