5-(cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-6-(4-nitrophenyl)pyrimidine

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Chemical Name:5-(cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-6-(4-nitrophenyl)pyrimidine
CAS No.:179481-02-8
Molecular Formula:C₃₄H₄₀N₆O₈
Molecular Weight:660.727
Hs Code.:

5-(cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-6-(4-nitrophenyl)pyrimidine

Synonyms:5-(cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-6-(4-nitrophenyl)pyrimidine

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Chemical Property of 5-(cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-6-(4-nitrophenyl)pyrimidine

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Technology Process of 5-(cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-6-(4-nitrophenyl)pyrimidine

There total 3 articles about 5-(cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-6-(4-nitrophenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 166809-18-3
3-[4-methoxycarbonyl-4-phenyl piperidin-1-yl]propylamine

: 179482-05-4,179482-09-8
5-(2-Cyanoethoxycarbonyl)-4-ethyl-1,6-dihydro-2-methoxy-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

: 179481-02-8
5-(cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-6-(4-nitrophenyl)pyrimidine

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm990200p

Reference yield:

: 172529-51-0
2-cyanoethyl 2-{(4-nitrophenyl)methylene}-3-oxopentanoate

: 179481-02-8
5-(cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-6-(4-nitrophenyl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / NaHCO₃ / ethanol / 5 h / 85 - 90 °C

2: 44 percent / aq. NaHCO₃ / CH₂Cl₂ / 10 h / 20 °C

3: 80 percent / K₂CO₃ / tetrahydrofuran / 1 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; 1: Condensation / 2: Carboxylation / 3: Condensation;
DOI:10.1021/jm990200p

Reference yield:

: 179482-04-3,179482-08-7
5-(2-cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-6-(4-nitrophenyl)pyrimidine

: 179481-02-8
5-(cyanoethoxycarbonyl)-1,6-dihydro-4-ethyl-2-methoxy-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-6-(4-nitrophenyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / aq. NaHCO₃ / CH₂Cl₂ / 10 h / 20 °C

2: 80 percent / K₂CO₃ / tetrahydrofuran / 1 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; dichloromethane; 1: Carboxylation / 2: Condensation;
DOI:10.1021/jm990200p