4-fluorophenyl diethyl phosphate

Base Information

• Chemical Name: 4-fluorophenyl diethyl phosphate
• CAS No.: 50672-36-1
• Molecular Formula: C₁₀H₁₄FO₄P
• Molecular Weight: 248.191
• Mol file: 50672-36-1.mol

Synonyms:4-fluorophenyl diethyl phosphate

Chemical Property of 4-fluorophenyl diethyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-fluorophenyl diethyl phosphate

There total 2 articles about 4-fluorophenyl diethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-Fluorophenol (371-41-5) + phosphonic acid diethyl ester (762-04-9) → 4-fluorophenyl diethyl phosphate (50672-36-1)

Guidance literature:

With tert.-butylhydroperoxide; lithium iodide; In water; acetonitrile; at 20 ℃; for 0.25h;

DOI:10.1002/ejoc.201901362

Reference yield:

4-Fluorophenol (371-41-5) + diethyl chlorophosphate (814-49-3) → 4-fluorophenyl diethyl phosphate (50672-36-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 23 ℃; for 18h;

DOI:10.1021/acs.biochem.9b00041

Reference yield:

4-fluorophenyl diethyl phosphate (50672-36-1) → C10H14FO4P

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 - 0 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02982

upstream raw materials:

4-Fluorophenol

phosphonic acid diethyl ester

diethyl chlorophosphate