6-chloro-2-[(4-methylphenyl)methyl]-1H-benzimidazole

Base Information

Chemical Name:6-chloro-2-[(4-methylphenyl)methyl]-1H-benzimidazole
CAS No.:111526-85-3
Molecular Formula:C₁₅H₁₃ClN₂
Molecular Weight:256.735
Hs Code.:
DSSTox Substance ID:DTXSID60877710
Nikkaji Number:J641.511C
Wikidata:Q82859551

Synonyms:111526-85-3;DTXSID60877710;2-(4-Methylphenylmethyl)-5-chlorobenzimidazole

Suppliers and Price of 6-chloro-2-[(4-methylphenyl)methyl]-1H-benzimidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-2-[(4-methylphenyl)methyl]-1H-benzimidazole

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:256.0767261
Heavy Atom Count:18
Complexity:276

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)CC2=NC3=C(N2)C=C(C=C3)Cl

Technology Process of 6-chloro-2-[(4-methylphenyl)methyl]-1H-benzimidazole

There total 1 articles about 6-chloro-2-[(4-methylphenyl)methyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 622-47-9
4-tolylacetic acid

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 111526-85-3
5-chloro-2-(4-methylbenzyl)-1H-benzo[d]imidazole

Guidance literature:: 4-tolylacetic acid; 4-Chloro-1,2-phenylenediamine; at 190 ℃; for 2h;

With sodium hydroxide; In water; at 5 ℃; for 24h;
DOI:10.1039/c3ob27404g

Reference yield:

: 111526-85-3
5-chloro-2-(4-methylbenzyl)-1H-benzo[d]imidazole

: 1433782-33-2
(5-chloro-1H-benzo[d]imidazol-2-yl)(p-tolyl)methanone

: 1433782-33-2
(6-chloro-1H-benzo[d]imidazol-2-yl)(p-tolyl)methanone

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 20h; Reagent/catalyst; Overall yield = 71 %; Overall yield = 71 mg;
DOI:10.1039/c3ob27404g