C₂₆H₃₄O₆

Base Information

• Chemical Name: C₂₆H₃₄O₆
• CAS No.: 219780-52-6
• Molecular Formula: C₂₆H₃₄O₆
• Molecular Weight: 442.552
• Mol file: 219780-52-6.mol

Synonyms:C₂₆H₃₄O₆

Chemical Property of C₂₆H₃₄O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₄O₆

There total 28 articles about C₂₆H₃₄O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

C32H48O6Si (219780-81-1) → C26H34O6 (219780-52-6) + C26H34O6 (219780-51-5)

Guidance literature:

C₃₂H₄₈O₆Si; With tetrabutyl ammonium fluoride; 2,6-di-tert-butyl-4-hydroxytoluene; In tetrahydrofuran; at 20 ℃; for 3h;

With sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 60h; Further stages.;

DOI:10.1021/ja9939439

Reference yield:

C39H62O6Si2 (219780-47-9) → C26H34O6 (219780-52-6)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 66 percent / diethyl zinc / toluene; hexane / 0.5 h / 0 °C

2.1: 77 percent / Dess-Martin periodinane / CH₂Cl₂ / 12 h / 20 °C

3.1: 84 percent / H₂ / Pd(OH)2 / ethanol / 0.5 h / 20 °C

4.1: pyridine / CH₂Cl₂ / 2 h / -45 °C

5.1: 0.742 g / TBAF; AcOH / tetrahydrofuran / 2.5 h / 20 °C

6.1: 86 percent / pyridinium p-toluenesulfonate / benzene / 1 h / Heating

7.1: 100 percent / K₂CO₃ / tetrahydrofuran; methanol / 1 h / 20 °C

8.1: 100 percent / SmI₂; methanol / tetrahydrofuran; hexamethylphosphoric acid triamide / 5 h / 20 °C

9.1: TBAF; 2,6-di-t-butyl-4-hydroxytoluene / tetrahydrofuran / 3 h / 20 °C

9.2: 45 percent / sodium methoxide / methanol; tetrahydrofuran / 60 h / 20 °C

With pyridine; methanol; samarium diiodide; tetrabutyl ammonium fluoride; hydrogen; diethylzinc; 2,6-di-tert-butyl-4-hydroxytoluene; pyridinium p-toluenesulfonate; potassium carbonate; Dess-Martin periodane; acetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; dichloromethane; toluene; benzene; 1.1: Cycloaddition / 2.1: Dess-Martin oxidation / 3.1: Hydrogenolysis / 4.1: cyclocondensation / 5.1: desilylation / 6.1: cyclocondensation / 7.1: Ring cleavage / 8.1: Ring cleavage / 9.1: desilylation / 9.2: Isomerization;

DOI:10.1021/ja9939439

Reference yield:

C40H62O6Si2 (219780-48-0) → C26H34O6 (219780-52-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 84 percent / H₂ / Pd(OH)2 / ethanol / 0.5 h / 20 °C

2.1: pyridine / CH₂Cl₂ / 2 h / -45 °C

3.1: 0.742 g / TBAF; AcOH / tetrahydrofuran / 2.5 h / 20 °C

4.1: 86 percent / pyridinium p-toluenesulfonate / benzene / 1 h / Heating

5.1: 100 percent / K₂CO₃ / tetrahydrofuran; methanol / 1 h / 20 °C

6.1: 100 percent / SmI₂; methanol / tetrahydrofuran; hexamethylphosphoric acid triamide / 5 h / 20 °C

7.1: TBAF; 2,6-di-t-butyl-4-hydroxytoluene / tetrahydrofuran / 3 h / 20 °C

7.2: 45 percent / sodium methoxide / methanol; tetrahydrofuran / 60 h / 20 °C

With pyridine; methanol; samarium diiodide; tetrabutyl ammonium fluoride; hydrogen; 2,6-di-tert-butyl-4-hydroxytoluene; pyridinium p-toluenesulfonate; potassium carbonate; acetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; benzene; 1.1: Hydrogenolysis / 2.1: cyclocondensation / 3.1: desilylation / 4.1: cyclocondensation / 5.1: Ring cleavage / 6.1: Ring cleavage / 7.1: desilylation / 7.2: Isomerization;

DOI:10.1021/ja9939439

upstream raw materials:

C₂₆H₃₄O₆

C₃₂H₄₈O₆Si

C₄₆H₆₆O₈Si₂

C₂₆H₄₀O₇Si

Downstream raw materials:

C₃₂H₄₈O₆Si

C₃₂H₃₇BO₆

7-(2,2,2-trichloroethyloxycarbonyl)baccatin III

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