3-chloro-N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Base Information

Chemical Name:3-chloro-N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide
CAS No.:1192021-65-0
Molecular Formula:C₁₃H₇Cl₂F₃N₂O₂
Molecular Weight:351.112
Hs Code.:

Synonyms:3-chloro-N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

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Chemical Property of 3-chloro-N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Chemical Property:

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Technology Process of 3-chloro-N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

There total 3 articles about 3-chloro-N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117338-13-3
2-amino-5-chloro-4-(trifluoromethyl)phenol

: 88912-27-0
3-chloro-isonicotinic acid

: 1192021-65-0
3-chloro-N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Guidance literature:: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 80 ℃; for 3h;

Reference yield:

: 400-70-4
2,4-dichloro-5-nitrobenzotrifluoride

: 1192021-65-0
3-chloro-N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / N,N-dimethyl-formamide / 3 h / 60 - 80 °C

2: iron / ethyl acetate; water; acetic acid / 80 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / pyridine / 3 h / 80 °C

With potassium acetate; iron; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In pyridine; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 5-chloro-2-nitro-4-(trifluoromethyl)phenol

: 1192021-65-0
3-chloro-N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron / ethyl acetate; water; acetic acid / 80 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / pyridine / 3 h / 80 °C

With iron; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In pyridine; water; acetic acid; ethyl acetate;