(2S,4S)-3-<2-Azido-2-(4-methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone

Base Information

Chemical Name:(2S,4S)-3-<2-Azido-2-(4-methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone
CAS No.:169176-61-8
Molecular Formula:C₁₉H₁₈N₄O₄
Molecular Weight:366.376
Hs Code.:

Synonyms:(2S,4S)-3-<2-Azido-2-(4-methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-3-<2-Azido-2-(4-methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone

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Technology Process of (2S,4S)-3-<2-Azido-2-(4-methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone

There total 4 articles about (2S,4S)-3-<2-Azido-2-(4-methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 143589-97-3
(4S)-3-<2-(4-Methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone

: (2R,4S)-3-<2-Azido-2-(4-methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone

: 169176-61-8
(2S,4S)-3-<2-Azido-2-(4-methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: With 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; Yields of byproduct given; 1.) 30 min, 2.) 2 min;
DOI:10.1021/jo00127a020

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 169176-61-8
(2S,4S)-3-<2-Azido-2-(4-methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 1.) -78 deg C, 20 min, 2.) room temp., 50 min

2: n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 deg C, 30 min; room temp., 20 h

3: 68 percent / KHMDS, trisyl azide / toluene; tetrahydrofuran / -78 °C / 1.) 30 min, 2.) 2 min

With n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo00127a020

Reference yield:

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 169176-61-8
(2S,4S)-3-<2-Azido-2-(4-methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 deg C, 30 min; room temp., 20 h

2: 68 percent / KHMDS, trisyl azide / toluene; tetrahydrofuran / -78 °C / 1.) 30 min, 2.) 2 min

With n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo00127a020