4-{8-[(8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifuoroacetate

Base Information

Chemical Name:4-{8-[(8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifuoroacetate
CAS No.:1350759-59-9
Molecular Formula:C₂HF₃O₂*C₂₆H₂₉ClN₂O₄
Molecular Weight:583.004
Hs Code.:

Synonyms:4-{8-[(8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifuoroacetate

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Chemical Property of 4-{8-[(8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifuoroacetate

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Technology Process of 4-{8-[(8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifuoroacetate

There total 5 articles about 4-{8-[(8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifuoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350761-27-1
8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromene-6-carbaldehyde

: 1350759-92-0
3-(4-carboxyphenyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene hydrochloride

: 76-05-1
trifluoroacetic acid

: 1350759-59-9
4-{8-[(8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifuoroacetate

Guidance literature:: 8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromene-6-carbaldehyde; 3-(4-carboxyphenyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene hydrochloride; With acetic acid; In N,N-dimethyl-formamide; at 55 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 42007-25-0
diphenyl 3-methyl-3-buten-1-yl phosphate

: 1350759-59-9
4-{8-[(8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifuoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 85 °C

2.1: aluminum (III) chloride / dichloromethane / -78 °C

3.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

3.2: -78 °C

4.1: acetic acid / N,N-dimethyl-formamide / 55 °C

With aluminum (III) chloride; n-butyllithium; caesium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1350761-23-7
4-bromo-2-chloro-1-[(3-methylbut-3-en-1-yl)oxy]benzene

: 1350759-59-9
4-{8-[(8-chloro-4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifuoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / dichloromethane / -78 °C

2.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

2.2: -78 °C

3.1: acetic acid / N,N-dimethyl-formamide / 55 °C

With aluminum (III) chloride; n-butyllithium; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;