10-O-acetyl-4'-O-p-nitrobenzoyl-3'-N-trifluoroacetyloxaunomycin

Base Information

• Chemical Name: 10-O-acetyl-4'-O-p-nitrobenzoyl-3'-N-trifluoroacetyloxaunomycin
• CAS No.: 132446-61-8
• Molecular Formula: C₃₇H₃₃F₃N₂O₁₅
• Molecular Weight: 802.669
• Mol file: 132446-61-8.mol

Synonyms:10-O-acetyl-4'-O-p-nitrobenzoyl-3'-N-trifluoroacetyloxaunomycin

Chemical Property of 10-O-acetyl-4'-O-p-nitrobenzoyl-3'-N-trifluoroacetyloxaunomycin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 10-O-acetyl-4'-O-p-nitrobenzoyl-3'-N-trifluoroacetyloxaunomycin

There total 1 articles about 10-O-acetyl-4'-O-p-nitrobenzoyl-3'-N-trifluoroacetyloxaunomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose (52583-22-9) + 10-O-acetyl-β-rhodomycinone (132489-76-0) → 10-O-acetyl-4'-O-p-nitrobenzoyl-3'-N-trifluoroacetyloxaunomycin (132446-61-8)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve;

DOI:10.1016/S0040-4039(00)97271-X

Reference yield:

10-O-acetyl-4'-O-p-nitrobenzoyl-3'-N-trifluoroacetyloxaunomycin (132446-61-8) → oxaunomycin (105615-58-5,103782-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 0.1 N NaOH / CH₂Cl₂; methanol / 0.5 h / 0 °C

2: 0.1 N NaOH / 1 h / 40 °C

With sodium hydroxide; In methanol; dichloromethane;

DOI:10.1248/cpb.40.61

upstream raw materials:

2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose

10-O-acetyl-β-rhodomycinone

Downstream raw materials:

oxaunomycin