(5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylic acid potassium salt

Base Information

Chemical Name:(5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylic acid potassium salt
CAS No.:117482-12-9
Molecular Formula:C₁₆H₁₅N₂O₅S*K
Molecular Weight:386.47
Hs Code.:

Synonyms:(5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylic acid potassium salt

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Chemical Property of (5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylic acid potassium salt

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Technology Process of (5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylic acid potassium salt

There total 9 articles about (5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylic acid potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117482-11-8
p-nitrobenzyl (5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylate

: 117482-12-9
(5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylic acid potassium salt

: (5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylic acid, sodium salt

Guidance literature:: With phosphate buffer; hydrogen; palladium on activated charcoal; In tetrahydrofuran; water; for 1.5h; under 2327.2 Torr; Yield given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1139/v88-225

Reference yield:

: 36954-98-0
methyl 6α-methyl-6-phenoxyacetamidopenicillanate

: 117482-12-9
(5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylic acid potassium salt

Guidance literature:: Multi-step reaction with 9 steps

1: 82 percent / ozone / acetone; H₂O / 0 - 5 °C

2: 1.)trimethyl phosphite 2.)triethylamine / 1.)85 deg C, 3 h 2.)ethyl acetate, 0-5 deg C, 4h

3: ozone / CH₂Cl₂; methanol / -25 °C

4: 50 percent / water / methanol; ethyl acetate / 18 h / 22 °C

5: triethylamine / CH₂Cl₂ / 1 h / 0 - 5 °C

6: 85 percent / thionyl chloride, pyridine / tetrahydrofuran / 0.25 h / -20 °C

7: 88 percent / 2,6-lutidine / tetrahydrofuran / 66 h / 50 °C

8: 72 percent / hydroquinone / toluene / 48 h / 100 °C

9: phosphate buffer (pH 7), hydrogen / Pd/C (10percent) / tetrahydrofuran; H₂O / 1.5 h / 2327.2 Torr / Ambient temperature

With pyridine; 2,6-dimethylpyridine; thionyl chloride; phosphate buffer; water; hydrogen; ozone; triethylamine; hydroquinone; phosphorous acid trimethyl ester; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetone; toluene;
DOI:10.1139/v88-225

Reference yield:

: 117482-07-2
4R-acetylthio-3R-methyl-3-phenoxyacetamido-2-azetidinone

: 117482-12-9
(5R) 6R-methyl-2-methyl-6-phenoxyacetamidopenem-3-carboxylic acid potassium salt

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / CH₂Cl₂ / 1 h / 0 - 5 °C

2: 85 percent / thionyl chloride, pyridine / tetrahydrofuran / 0.25 h / -20 °C

3: 88 percent / 2,6-lutidine / tetrahydrofuran / 66 h / 50 °C

4: 72 percent / hydroquinone / toluene / 48 h / 100 °C

5: phosphate buffer (pH 7), hydrogen / Pd/C (10percent) / tetrahydrofuran; H₂O / 1.5 h / 2327.2 Torr / Ambient temperature

With pyridine; 2,6-dimethylpyridine; thionyl chloride; phosphate buffer; hydrogen; triethylamine; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1139/v88-225