cis-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:cis-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:88156-89-2
Molecular Formula:C₂₄H₂₄N₂O₄
Molecular Weight:404.466
Hs Code.:

Synonyms:cis-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of cis-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of cis-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 4 articles about cis-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 88156-87-0
cis-6-Hydroxy-7-methoxy-N-methyl-N-(p-nitrobenzyl)-1-phenyl-1,2,3,4-tetrahydroisoquinolinium Bromide

: 88156-89-2
cis-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 88156-88-1
trans-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; at 35 ℃; for 18h;
DOI:10.1021/jo00178a001

Reference yield: 61.0%

: 88156-86-9
trans-6-Hydroxy-7-methoxy-N-methyl-N-(p-nitrobenzyl)-1-phenyl-1,2,3,4-tetrahydroisoquinolinium Bromide

: 88156-89-2
cis-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 88156-88-1
trans-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; at 35 ℃; for 18h;
DOI:10.1021/jo00178a001

Reference yield:

: 55161-45-0
7-methoxy-2-methyl-1-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol

: 88156-89-2
cis-7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 1.5 h / Heating

2: 22 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 18 h / 35 °C

With potassium tert-butylate; In acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo00178a001