N-((2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)methyl)-cyclohexanamine

Base Information

Chemical Name:N-((2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)methyl)-cyclohexanamine
CAS No.:1342891-25-1
Molecular Formula:C₁₇H₂₄N₂O
Molecular Weight:272.39
Hs Code.:

Synonyms:N-((2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)methyl)-cyclohexanamine

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Chemical Property of N-((2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)methyl)-cyclohexanamine

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Technology Process of N-((2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)methyl)-cyclohexanamine

There total 9 articles about N-((2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)methyl)-cyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1342891-23-9
N-((8-bromo-2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)-methyl)cyclohexanamine

: 1342891-25-1
N-((2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)methyl)-cyclohexanamine

Guidance literature:: N-((8-bromo-2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)-methyl)cyclohexanamine; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With n-butyllithium; at -78 ℃; for 1h;
DOI:10.1021/jm201018g

Reference yield: 50.0%

: 1342891-25-1
N-((2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)methyl)-cyclohexanamine

Guidance literature:

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 1342891-25-1
N-((2,2-dimethyl-2H-pyrano[2,3-c]pyridin-6-yl)methyl)-cyclohexanamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine; bromine / 0 °C

2.1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran

3.1: trifluoroacetic anhydride / 24 h / 40 °C

4.1: copper(II) choride dihydrate; potassium carbonate; potassium iodide / acetone / 0.17 h / 60 °C

5.1: toluene / 1 h / 120 °C / Microwave irradiation

6.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

8.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

8.2: 1 h / -78 °C

With pyridine; copper(II) choride dihydrate; carbon tetrabromide; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic anhydride; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm201018g