[(S)-2-Benzyloxy-prop-(E)-ylidene]-[bis-(4-methoxy-phenyl)-methyl]-amine

Base Information

• Chemical Name: [(S)-2-Benzyloxy-prop-(E)-ylidene]-[bis-(4-methoxy-phenyl)-methyl]-amine
• CAS No.: 115026-42-1
• Molecular Formula: C₂₅H₂₇NO₃
• Molecular Weight: 389.494
• Mol file: 115026-42-1.mol

Synonyms:[(S)-2-Benzyloxy-prop-(E)-ylidene]-[bis-(4-methoxy-phenyl)-methyl]-amine

Chemical Property of [(S)-2-Benzyloxy-prop-(E)-ylidene]-[bis-(4-methoxy-phenyl)-methyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-2-Benzyloxy-prop-(E)-ylidene]-[bis-(4-methoxy-phenyl)-methyl]-amine

There total 3 articles about [(S)-2-Benzyloxy-prop-(E)-ylidene]-[bis-(4-methoxy-phenyl)-methyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p,p'-dimethoxybenzhydrylamine (19293-62-0) + (S)-2-(benzyloxy)propanal (81445-44-5) → [(S)-2-Benzyloxy-prop-(E)-ylidene]-[bis-(4-methoxy-phenyl)-methyl]-amine (115026-42-1)

Guidance literature:

With magnesium sulfate; In toluene;

DOI:10.1016/S0040-4039(00)85317-4

Reference yield:

O-benzyl 2,2,2-trichloroacetimidate (81927-55-1) → [(S)-2-Benzyloxy-prop-(E)-ylidene]-[bis-(4-methoxy-phenyl)-methyl]-amine (115026-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / TfOH

2: 82 percent / diisobutylaluminium hydride / diethyl ether / -78 °C

3: magnesium sulfate / toluene

With diisobutylaluminium hydride; magnesium sulfate; trifluorormethanesulfonic acid; In diethyl ether; toluene;

DOI:10.1016/S0040-4039(00)85317-4

Reference yield:

ethyl (S)-2-(benzyloxy)propionate (54783-72-1) → [(S)-2-Benzyloxy-prop-(E)-ylidene]-[bis-(4-methoxy-phenyl)-methyl]-amine (115026-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / diisobutylaluminium hydride / diethyl ether / -78 °C

2: magnesium sulfate / toluene

With diisobutylaluminium hydride; magnesium sulfate; In diethyl ether; toluene;

DOI:10.1016/S0040-4039(00)85317-4

upstream raw materials:

p,p'-dimethoxybenzhydrylamine

(S)-2-(benzyloxy)propanal

O-benzyl 2,2,2-trichloroacetimidate

ethyl (S)-2-(benzyloxy)propionate

Downstream raw materials:

(3S,4S)-3-acetyl-4-<(S)-1-benzyloxyethyl>-1-(di-p-anisylmethyl)-2-azetidinone

(3R,4R)-3-acetyl-4-<(S)-1-benzyloxyethyl>-1-(di-p-anisylmethyl)-2-azetidinone

(3R,4R)-3-Acetyl-4-((R)-1-benzyloxy-ethyl)-1-[bis-(4-methoxy-phenyl)-methyl]-azetidin-2-one

(3S,4R)-3-Benzyloxy-4-((S)-1-benzyloxy-ethyl)-azetidin-2-one