Technology Process of N5,N18-dibenzyl-N1,N9,N14,N22-tetratosyl-1,5,9,14,18,22-hexaazacyclohexacosane
There total 7 articles about N5,N18-dibenzyl-N1,N9,N14,N22-tetratosyl-1,5,9,14,18,22-hexaazacyclohexacosane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 96h;
DOI:10.1246/bcsj.73.693
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / sodium hydrogen carbonate / acetonitrile / 70 h / 70 °C
2: 99 percent / potassium carbonate / dimethylformamide / 96 h / 20 °C
3: 90 percent / hydrazine hydrate / 48 h / 75 °C
4: aq. HCl / CHCl3 / 5 h / 65 °C
5: triethylamine / pyridine / 20 °C
6: 59 percent / potassium carbonate / dimethylformamide / 96 h / 20 °C
With
hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; hydrazine hydrate; triethylamine;
In
pyridine; chloroform; N,N-dimethyl-formamide; acetonitrile;
1: Alkylation / 2: Alkylation / 3: Formylation / 4: Hydrolysis / 5: Tosylation / 6: Cyclization;
DOI:10.1246/bcsj.73.693
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / potassium carbonate / dimethylformamide / 96 h / 20 °C
2: 90 percent / hydrazine hydrate / 48 h / 75 °C
3: aq. HCl / CHCl3 / 5 h / 65 °C
4: triethylamine / pyridine / 20 °C
5: 59 percent / potassium carbonate / dimethylformamide / 96 h / 20 °C
With
hydrogenchloride; potassium carbonate; hydrazine hydrate; triethylamine;
In
pyridine; chloroform; N,N-dimethyl-formamide;
1: Alkylation / 2: Formylation / 3: Hydrolysis / 4: Tosylation / 5: Cyclization;
DOI:10.1246/bcsj.73.693
