Technology Process of bis(4-amino-2,5-difluorophenyl)methanone
There total 4 articles about bis(4-amino-2,5-difluorophenyl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium hydroxide;
In
water; dimethyl sulfoxide;
at 110 ℃;
for 12h;
DOI:10.1021/jo202062f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / 3 h / -78 - 4 °C
1.2: -78 - 23 °C
2.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane; water / 3 h
3.1: ammonium hydroxide / water; dimethyl sulfoxide / 12 h / 110 °C
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; isopropylmagnesium chloride; sodium hydrogencarbonate; ammonium hydroxide; potassium bromide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jo202062f
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane; water / 3 h
2: ammonium hydroxide / water; dimethyl sulfoxide / 12 h / 110 °C
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; ammonium hydroxide; potassium bromide;
In
dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jo202062f
