1-(3-Hydroxy-7,8-dimethoxy-1-methyl-isoquinolin-4-yl)-3-(3-methoxy-phenyl)-urea

Base Information

Chemical Name:1-(3-Hydroxy-7,8-dimethoxy-1-methyl-isoquinolin-4-yl)-3-(3-methoxy-phenyl)-urea
CAS No.:118576-06-0
Molecular Formula:C₂₀H₂₁N₃O₅
Molecular Weight:383.404
Hs Code.:

Synonyms:1-(3-Hydroxy-7,8-dimethoxy-1-methyl-isoquinolin-4-yl)-3-(3-methoxy-phenyl)-urea

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Chemical Property of 1-(3-Hydroxy-7,8-dimethoxy-1-methyl-isoquinolin-4-yl)-3-(3-methoxy-phenyl)-urea

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Technology Process of 1-(3-Hydroxy-7,8-dimethoxy-1-methyl-isoquinolin-4-yl)-3-(3-methoxy-phenyl)-urea

There total 7 articles about 1-(3-Hydroxy-7,8-dimethoxy-1-methyl-isoquinolin-4-yl)-3-(3-methoxy-phenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18028-29-0
4-bromo-6,7-dimethoxy-1-indanone

: 118576-06-0
1-(3-Hydroxy-7,8-dimethoxy-1-methyl-isoquinolin-4-yl)-3-(3-methoxy-phenyl)-urea

Guidance literature:: Multi-step reaction with 8 steps

1: 2) conc. HCl / 1) Et₂O, benzene, 3 h, reflux, 2) 0.5 h

2: 47 percent / CrO₃, conc. H₂SO₄ / acetone; H₂O / 3 h / Ambient temperature

3: 85 percent / conc. HCl / 3 h / Heating

4: 97 percent / H₂, AcOH, NaOAc / 10percent Pd/C

5: 87 percent / NH₄OAc / 1 h / 160 °C

6: 41 percent / 90percent HNO₃ / diethyl ether / 0.17 h

7: H₂, gl. AcOH / 10percent Pd/C / 879.2 Torr / Ambient temperature

8: AcOH

With chromium(VI) oxide; hydrogenchloride; sulfuric acid; ammonium acetate; hydrogen; nitric acid; sodium acetate; acetic acid; palladium on activated charcoal; In diethyl ether; water; acetone;
DOI:10.1021/jm00125a011

Reference yield:

: 118575-92-1
Methyl 2-acetyl-3,4-dimethoxyphenylacetate

: 118576-06-0
1-(3-Hydroxy-7,8-dimethoxy-1-methyl-isoquinolin-4-yl)-3-(3-methoxy-phenyl)-urea

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / NH₄OAc / 1 h / 160 °C

2: 41 percent / 90percent HNO₃ / diethyl ether / 0.17 h

3: H₂, gl. AcOH / 10percent Pd/C / 879.2 Torr / Ambient temperature

4: AcOH

With ammonium acetate; hydrogen; nitric acid; acetic acid; palladium on activated charcoal; In diethyl ether;
DOI:10.1021/jm00125a011

Reference yield:

: 114130-58-4
3-Hydroxy-7,8-dimethoxy-1-methylisoquinoline

: 118576-06-0
1-(3-Hydroxy-7,8-dimethoxy-1-methyl-isoquinolin-4-yl)-3-(3-methoxy-phenyl)-urea

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / 90percent HNO₃ / diethyl ether / 0.17 h

2: H₂, gl. AcOH / 10percent Pd/C / 879.2 Torr / Ambient temperature

3: AcOH

With hydrogen; nitric acid; acetic acid; palladium on activated charcoal; In diethyl ether;
DOI:10.1021/jm00125a011