(-)-N-<(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(R)-3-chloromandelamide

Base Information

Chemical Name:(-)-N-<(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(R)-3-chloromandelamide
CAS No.:121251-84-1
Molecular Formula:C₁₈H₁₈ClNO₃
Molecular Weight:331.799
Hs Code.:

Synonyms:(-)-N-<(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(R)-3-chloromandelamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-N-<(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(R)-3-chloromandelamide

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Technology Process of (-)-N-<(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(R)-3-chloromandelamide

There total 5 articles about (-)-N-<(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(R)-3-chloromandelamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.4%

: 16273-37-3,32222-43-8,52950-16-0,61008-98-8
(R)-3-chloromandelic acid

: 85951-60-6
(-)-7-OH-AT

: 121251-84-1
(-)-N-<(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(R)-3-chloromandelamide

Guidance literature:: With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1016/0223-5234(94)90095-7

Reference yield:

: S(-)-2-amino-7-hydroxytetralin monohydrate

: 16273-37-3,32222-43-8,52950-16-0,61008-98-8
(R)-3-chloromandelic acid

: 121251-84-1
(-)-N-<(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(R)-3-chloromandelamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; cyclohexane; ethyl acetate;

Reference yield:

: 4003-89-8,118298-16-1
2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene

: 121251-84-1
(-)-N-<(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(R)-3-chloromandelamide

Guidance literature:: Multi-step reaction with 3 steps

2: 30 percent / 1.) 48percent HBr aq., 2.) NH₄OH / 3 h / Heating

3: 63.4 percent / benzotriazol-1-yloxy-tris(dimethylamino)hposphonium hexafluorophosphate, TEA / CH₂Cl₂ / 5 h / Ambient temperature

With ammonium hydroxide; TEA; hydrogen bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane;
DOI:10.1016/0223-5234(94)90095-7