2,3-O-isopropylidene-γ-D-ribonolactone (2R)-2-(4-bromobenzyl)-2-butylacetoacetate

Base Information

Chemical Name:2,3-O-isopropylidene-γ-D-ribonolactone (2R)-2-(4-bromobenzyl)-2-butylacetoacetate
CAS No.:259800-76-5
Molecular Formula:C₂₃H₂₉BrO₇
Molecular Weight:497.383
Hs Code.:

Synonyms:2,3-O-isopropylidene-γ-D-ribonolactone (2R)-2-(4-bromobenzyl)-2-butylacetoacetate

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Chemical Property of 2,3-O-isopropylidene-γ-D-ribonolactone (2R)-2-(4-bromobenzyl)-2-butylacetoacetate

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Technology Process of 2,3-O-isopropylidene-γ-D-ribonolactone (2R)-2-(4-bromobenzyl)-2-butylacetoacetate

There total 2 articles about 2,3-O-isopropylidene-γ-D-ribonolactone (2R)-2-(4-bromobenzyl)-2-butylacetoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30725-00-9
2,3-O-isopropylidene-D-ribonic-γ-lactone

: 259800-76-5
2,3-O-isopropylidene-γ-D-ribonolactone (2R)-2-(4-bromobenzyl)-2-butylacetoacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82 percent / toluene / 24 h / 130 °C

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 71 percent / tetrahydrofuran / 24 h / Heating

3.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

3.2: 44 percent / tetrahydrofuran / 12 h / 20 °C

With sodium hydride; In tetrahydrofuran; toluene; 1.1: Condensation / 2.1: Metallation / 2.2: Substitution / 3.1: Metallation / 3.2: Substitution;
DOI:10.1016/S0957-4166(99)00457-7

Reference yield:

: 89747-52-4
2,3-O-isopropylidene-γ-D-ribonolactone acetoacetate

: 259800-76-5
2,3-O-isopropylidene-γ-D-ribonolactone (2R)-2-(4-bromobenzyl)-2-butylacetoacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

1.2: 71 percent / tetrahydrofuran / 24 h / Heating

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 44 percent / tetrahydrofuran / 12 h / 20 °C

With sodium hydride; In tetrahydrofuran; 1.1: Metallation / 1.2: Substitution / 2.1: Metallation / 2.2: Substitution;
DOI:10.1016/S0957-4166(99)00457-7